TY - JOUR
T1 - Differentiation Between Pediatric Irritable Bowel Syndrome and Inflammatory Bowel Disease Based on Fecal Scent: Proof of Principle Study
AU - Bosch, Sofie
AU - van Gaal, Nora
AU - Zuurbier, Roy P.
AU - Covington, James A.
AU - Wicaksono, Alfian N.
AU - Biezeveld, Maarten H.
AU - Benninga, Marc A.
AU - Mulder, Chris J.
AU - de Boer, Nanne K. H.
AU - de Meij, Tim G. J.
PY - 2018
Y1 - 2018
N2 - Background: The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of noninvasive diagnostic biomarkers for IBS and FAP-NOS. Several studies have shown microbiota alterations in IBS/FAP, which are considered to be reflected by fecal volatile organic compounds (VOCs). The object of the study was to evaluate whether pediatric IBS/FAP-NOS could be discriminated from IBD and healthy controls by fecal VOC analysis.
AB - Background: The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of noninvasive diagnostic biomarkers for IBS and FAP-NOS. Several studies have shown microbiota alterations in IBS/FAP, which are considered to be reflected by fecal volatile organic compounds (VOCs). The object of the study was to evaluate whether pediatric IBS/FAP-NOS could be discriminated from IBD and healthy controls by fecal VOC analysis.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049476078&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29788410
U2 - https://doi.org/10.1093/ibd/izy151
DO - https://doi.org/10.1093/ibd/izy151
M3 - Article
C2 - 29788410
SN - 1078-0998
VL - 24
SP - 2468
EP - 2475
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
IS - 11
ER -