Differentiation of hepatocellular adenoma and focal nodular hyperplasia using (18)F-fluorocholine PET/CT

Jacomina W. van den Esschert; Matthanja Bieze; Ulrich H. Beuers; Thomas M. van Gulik; Roelof J. Bennink

doi:https://doi.org/10.1007/s00259-010-1584-0

Differentiation of hepatocellular adenoma and focal nodular hyperplasia using (18)F-fluorocholine PET/CT

Jacomina W. van den Esschert, Matthanja Bieze, Ulrich H. Beuers, Thomas M. van Gulik, Roelof J. Bennink

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The aim of this pilot study was to evaluate the use of PET/CT with (18)F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). Patients with liver lesions larger than 2 cm suspicious for HCA or FNH were prospectively included. All patients underwent PET/CT with (18)F-fluorocholine and histopathological diagnosis was obtained by either liver biopsy or surgery. The ratios between the maximum standardized uptake value (SUV) of the lesion and the mean SUV of normal liver parenchyma were calculated and a receiver operating characteristic (ROC) curve analysis was performed. Ten patients with FNH and 11 with HCA were included. The mean SUV ratio was 1.68±0.29 (±SD) for FNH and 0.88±0.18 for HCA (p <0.001). An SUV ratio cut-off value between 1.12 and 1.22 differentiated patients with FNH from those with HCA with 100% sensitivity and 100% specificity. This pilot study showed that PET/CT with (18)F-fluorocholine can differentiate HCA from FNH

Original language	English
Pages (from-to)	436-440
Journal	European journal of nuclear medicine and molecular imaging
Volume	38
Issue number	3
DOIs	https://doi.org/10.1007/s00259-010-1584-0
Publication status	Published - 2011

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https://doi.org/10.1007/s00259-010-1584-0

Cite this

@article{2261d82416c64ebab66dda8e02855f2d,

title = "Differentiation of hepatocellular adenoma and focal nodular hyperplasia using (18)F-fluorocholine PET/CT",

abstract = "The aim of this pilot study was to evaluate the use of PET/CT with (18)F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). Patients with liver lesions larger than 2 cm suspicious for HCA or FNH were prospectively included. All patients underwent PET/CT with (18)F-fluorocholine and histopathological diagnosis was obtained by either liver biopsy or surgery. The ratios between the maximum standardized uptake value (SUV) of the lesion and the mean SUV of normal liver parenchyma were calculated and a receiver operating characteristic (ROC) curve analysis was performed. Ten patients with FNH and 11 with HCA were included. The mean SUV ratio was 1.68±0.29 (±SD) for FNH and 0.88±0.18 for HCA (p <0.001). An SUV ratio cut-off value between 1.12 and 1.22 differentiated patients with FNH from those with HCA with 100% sensitivity and 100% specificity. This pilot study showed that PET/CT with (18)F-fluorocholine can differentiate HCA from FNH",

author = "{van den Esschert}, {Jacomina W.} and Matthanja Bieze and Beuers, {Ulrich H.} and {van Gulik}, {Thomas M.} and Bennink, {Roelof J.}",

year = "2011",

doi = "https://doi.org/10.1007/s00259-010-1584-0",

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T1 - Differentiation of hepatocellular adenoma and focal nodular hyperplasia using (18)F-fluorocholine PET/CT

AU - van den Esschert, Jacomina W.

AU - Bieze, Matthanja

AU - Beuers, Ulrich H.

AU - van Gulik, Thomas M.

AU - Bennink, Roelof J.

PY - 2011

Y1 - 2011

N2 - The aim of this pilot study was to evaluate the use of PET/CT with (18)F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). Patients with liver lesions larger than 2 cm suspicious for HCA or FNH were prospectively included. All patients underwent PET/CT with (18)F-fluorocholine and histopathological diagnosis was obtained by either liver biopsy or surgery. The ratios between the maximum standardized uptake value (SUV) of the lesion and the mean SUV of normal liver parenchyma were calculated and a receiver operating characteristic (ROC) curve analysis was performed. Ten patients with FNH and 11 with HCA were included. The mean SUV ratio was 1.68±0.29 (±SD) for FNH and 0.88±0.18 for HCA (p <0.001). An SUV ratio cut-off value between 1.12 and 1.22 differentiated patients with FNH from those with HCA with 100% sensitivity and 100% specificity. This pilot study showed that PET/CT with (18)F-fluorocholine can differentiate HCA from FNH

AB - The aim of this pilot study was to evaluate the use of PET/CT with (18)F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). Patients with liver lesions larger than 2 cm suspicious for HCA or FNH were prospectively included. All patients underwent PET/CT with (18)F-fluorocholine and histopathological diagnosis was obtained by either liver biopsy or surgery. The ratios between the maximum standardized uptake value (SUV) of the lesion and the mean SUV of normal liver parenchyma were calculated and a receiver operating characteristic (ROC) curve analysis was performed. Ten patients with FNH and 11 with HCA were included. The mean SUV ratio was 1.68±0.29 (±SD) for FNH and 0.88±0.18 for HCA (p <0.001). An SUV ratio cut-off value between 1.12 and 1.22 differentiated patients with FNH from those with HCA with 100% sensitivity and 100% specificity. This pilot study showed that PET/CT with (18)F-fluorocholine can differentiate HCA from FNH

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DO - https://doi.org/10.1007/s00259-010-1584-0

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SN - 1619-7070

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JO - European journal of nuclear medicine and molecular imaging

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