Difficulties with diagnosis of malignancies in pregnancy

J. de Haan, V. Vandecaveye, S. N. Han, K. K. van de Vijver, F. Amant

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)


Diagnosis and staging of cancer during pregnancy may be difficult due to overlap in physical signs, uncertainties on safety and accuracy of diagnostic tests and histopathology in pregnant women. Tumour markers should be used with caution due to pregnancy-induced elevation. Ionizing imaging and staging techniques such as computed tomography (CT) or positron emission tomography (PET) scans and sentinel node procedures are safe during pregnancy when fetal radiation threshold of 100 mGy is maintained. Ionizing imaging techniques can increasingly be avoided with the technical devolvement of non-ionizing techniques such as magnetic resonance imaging (MRI), including whole body MRI and diffusion-weighted imaging, which hold potentially great opportunities for the diagnostic management of pregnant cancer patients. Pathological evaluation and establishing a diagnosis of malignancy can be difficult in pregnant women, and a note to the pathologist of the pregnant status is essential for accurate diagnosis. This chapter will give an overview of possibilities and difficulties in diagnosing pregnant women with cancer
Original languageEnglish
Pages (from-to)19-32
Number of pages14
JournalBest practice & research. Clinical obstetrics & gynaecology
Publication statusPublished - May 2016


  • Biomarkers, Tumor/blood
  • Biopsy
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Multimodal Imaging
  • Neoplasm Staging
  • Pregnancy
  • Pregnancy Complications, Neoplastic/diagnosis
  • Radionuclide Imaging
  • Sentinel Lymph Node Biopsy
  • Tomography, X-Ray Computed
  • Ultrasonography

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