Disability in people clinically at high risk of psychosis

Background Decline in social functioning occurs in individuals who later develop psychosis. Aims To investigate whether baseline differences in disability are present in those who do and those who do not make a transition to psychosis in a group clinically at high risk and whether disability is a risk factor for transition. Method Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking individuals clinically at high risk. Disability was assessed with the Disability Assessment Schedule of the World Health Organization (WHODAS-II). Results At baseline, the transition group displayed significantly greater difficulties in making new friends (z = -3.40, P=0.001), maintaining a friendship (z = -3.00, P = 0.003), dealing with people they do not know (z = -2.28, P = 0.023) and joining community activities (z = -2.0, P = 0.05) compared with the non-transition group. In Cox regression, difficulties in getting along with people significantly contributed to the prediction of transition to psychosis in our sample (beta=0.569, s.e. = 0.184, Wald = 9.548, P = 0.002, hazard ratio (HR) = 1.767, 95% CI 1.238-2.550). Conclusions Certain domains of social disability might contribute to the prediction of psychosis in a sample clinically at high risk