Discordant responses during antiretroviral therapy role of immune activation and T cell redistribution rather than true CD4 T cell loss

Mette D. Hazenberg; Sigrid A. Otto; Ferdinand W. N. M. Wit; Joep M. A. Lange; Dörte Hamann; Frank Miedema

doi:https://doi.org/10.1097/00002030-200206140-00013

Discordant responses during antiretroviral therapy role of immune activation and T cell redistribution rather than true CD4 T cell loss

Mette D. Hazenberg, Sigrid A. Otto, Ferdinand W. N. M. Wit, Joep M. A. Lange, Dörte Hamann, Frank Miedema

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Scopus)

Abstract

We studied T cell dynamics in four patients who initially responded well to highly active antiretroviral therapy (HA-ART) but subsequently experienced virological failure. Maintenance of peripheral blood CD4T cell counts was associated with low levels of immune activation. Low reactivity to rebounding virus may preserve normal T lymphocyte distribution over blood and tissues and be associated with stable peripheral blood T cell numbers in virological failures to HAART

Original language	English
Pages (from-to)	1287-1289
Journal	AIDS (London, England)
Volume	16
Issue number	9
DOIs	https://doi.org/10.1097/00002030-200206140-00013
Publication status	Published - 2002

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https://doi.org/10.1097/00002030-200206140-00013

Cite this

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title = "Discordant responses during antiretroviral therapy role of immune activation and T cell redistribution rather than true CD4 T cell loss",

abstract = "We studied T cell dynamics in four patients who initially responded well to highly active antiretroviral therapy (HA-ART) but subsequently experienced virological failure. Maintenance of peripheral blood CD4T cell counts was associated with low levels of immune activation. Low reactivity to rebounding virus may preserve normal T lymphocyte distribution over blood and tissues and be associated with stable peripheral blood T cell numbers in virological failures to HAART",

author = "Hazenberg, {Mette D.} and Otto, {Sigrid A.} and Wit, {Ferdinand W. N. M.} and Lange, {Joep M. A.} and D{\"o}rte Hamann and Frank Miedema",

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AU - Hazenberg, Mette D.

AU - Otto, Sigrid A.

AU - Wit, Ferdinand W. N. M.

AU - Lange, Joep M. A.

AU - Hamann, Dörte

AU - Miedema, Frank

PY - 2002

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AB - We studied T cell dynamics in four patients who initially responded well to highly active antiretroviral therapy (HA-ART) but subsequently experienced virological failure. Maintenance of peripheral blood CD4T cell counts was associated with low levels of immune activation. Low reactivity to rebounding virus may preserve normal T lymphocyte distribution over blood and tissues and be associated with stable peripheral blood T cell numbers in virological failures to HAART

U2 - https://doi.org/10.1097/00002030-200206140-00013

DO - https://doi.org/10.1097/00002030-200206140-00013

M3 - Article

C2 - 12045496

SN - 0269-9370

VL - 16

SP - 1287

EP - 1289

JO - AIDS (London, England)

JF - AIDS (London, England)

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