Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

C. Granchi; S. Roy; C. Giacomelli; M. Macchia; T. Tuccinardi; A. Martinelli; M. Lanza; L. Betti; G. Giannaccini; A. Lucacchini; N. Funel; L.G. Leon; E. Giovannetti; G.J. Peters; R. Palchaudhuri; E.C. Calvaresi; P.J. Hergenrother; F. Minutolo

doi:https://doi.org/10.1021/jm101007q

Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

C. Granchi, S. Roy, C. Giacomelli, M. Macchia, T. Tuccinardi, A. Martinelli, M. Lanza, L. Betti, G. Giannaccini, A. Lucacchini, N. Funel, L.G. Leon, E. Giovannetti, G.J. Peters, R. Palchaudhuri, E.C. Calvaresi, P.J. Hergenrother, F. Minutolo

Medical oncology laboratory (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

180 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	1599-1612
Journal	Journal of Medicinal Chemistry
Volume	54
Issue number	6
DOIs	https://doi.org/10.1021/jm101007q
Publication status	Published - 2011

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https://doi.org/10.1021/jm101007q

Cite this

Granchi, C., Roy, S., Giacomelli, C., Macchia, M., Tuccinardi, T., Martinelli, A., Lanza, M., Betti, L., Giannaccini, G., Lucacchini, A., Funel, N., Leon, L. G., Giovannetti, E., Peters, G. J., Palchaudhuri, R., Calvaresi, E. C., Hergenrother, P. J., & Minutolo, F. (2011). Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells. Journal of Medicinal Chemistry, 54(6), 1599-1612. https://doi.org/10.1021/jm101007q

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author = "C. Granchi and S. Roy and C. Giacomelli and M. Macchia and T. Tuccinardi and A. Martinelli and M. Lanza and L. Betti and G. Giannaccini and A. Lucacchini and N. Funel and L.G. Leon and E. Giovannetti and G.J. Peters and R. Palchaudhuri and E.C. Calvaresi and P.J. Hergenrother and F. Minutolo",

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Granchi, C, Roy, S, Giacomelli, C, Macchia, M, Tuccinardi, T, Martinelli, A, Lanza, M, Betti, L, Giannaccini, G, Lucacchini, A, Funel, N, Leon, LG, Giovannetti, E , Peters, GJ, Palchaudhuri, R, Calvaresi, EC, Hergenrother, PJ & Minutolo, F 2011, 'Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells', Journal of Medicinal Chemistry, vol. 54, no. 6, pp. 1599-1612. https://doi.org/10.1021/jm101007q

TY - JOUR

T1 - Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

AU - Granchi, C.

AU - Roy, S.

AU - Giacomelli, C.

AU - Macchia, M.

AU - Tuccinardi, T.

AU - Martinelli, A.

AU - Lanza, M.

AU - Betti, L.

AU - Giannaccini, G.

AU - Lucacchini, A.

AU - Funel, N.

AU - Leon, L.G.

AU - Giovannetti, E.

AU - Peters, G.J.

AU - Palchaudhuri, R.

AU - Calvaresi, E.C.

AU - Hergenrother, P.J.

AU - Minutolo, F.

PY - 2011

Y1 - 2011

U2 - https://doi.org/10.1021/jm101007q

DO - https://doi.org/10.1021/jm101007q

M3 - Article

C2 - 21332213

SN - 0022-2623

VL - 54

SP - 1599

EP - 1612

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 6

ER -