TY - JOUR
T1 - Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD
AU - Jiang, Wenhao
AU - Rootes-Murdy, Kelly
AU - Duan, Kuaikuai
AU - Schoenmacker, Gido
AU - Hoekstra, Pieter J.
AU - Hartman, Catharina A.
AU - Oosterlaan, Jaap
AU - Heslenfeld, Dirk
AU - Franke, Barbara
AU - Sprooten, Emma
AU - Buitelaar, Jan
AU - Arias-Vasquez, Alejandro
AU - Liu, Jingyu
AU - Turner, Jessica A.
N1 - Funding Information: This study was supported by the National Institutes of Health and The National Institute of Mental Health through the grant 1R01MH106655 . This NeuroIMAGE study was supported by NIH Grant R01MH62873 , NWO Large Investment Grant 1750102007010 and grants from Radboud University Medical Center, University Medical Center Groningen and Accare, and VU University Amsterdam. This work was also supported by grants from NWO Brain & Cognition ( 433–09–242 and 056–13–015 ) and from ZonMW (60–60600–97–193). Further support was received from the European Union's FP7 program under grant agreement no. 278948 (TACTICS), no. 602450 (IMAGEMEND), no. 602805 (Aggressotype), and from the European Union's Horizon 2020 research and innovation program under grant agreement no. 667302 (CoCA) and no. 728018 (Eat2beNICE). Barbara Franke receives funding from a personal Vici grant (to Barbara Franke) of the Netherlands Organization for Scientific Research (NWO, grant numbers 433–09–229 and 016–130–669 ) and a pilot grant of the Dutch National Research Agenda for the NeuroLabNL project. Publisher Copyright: © 2021
PY - 2021/5/30
Y1 - 2021/5/30
N2 - A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.
AB - A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.
UR - http://www.scopus.com/inward/record.url?scp=85103113221&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.pscychresns.2021.111282
DO - https://doi.org/10.1016/j.pscychresns.2021.111282
M3 - Article
C2 - 33780745
SN - 0925-4927
VL - 311
SP - 1
EP - 4
JO - PSYCHIATRY RESEARCH-NEUROIMAGING
JF - PSYCHIATRY RESEARCH-NEUROIMAGING
M1 - 111282
ER -