Abstract
Imaging of human autopsy samples was performed from the luminal side with a high (3.5 μm axial and 7 μm lateral) resolution OCT system (around 800 nm) or a regular (15-20 μm axial and 20 μm lateral resolution) OCT system (around 1300 run). For each sample, dimensions were measured by histomorphometry and OCT and the optical attenuation was measured. Quantitative analysis showed a strong and significant correlation between OCT and histology cap thickness measurements for both OCT systems. For both systems, the measured attenuation coefficients of diffuse intimai thickening and lipid-rich regions differed significantly from media and calcifications. Both the high and regular resolution OCT systems can precisely image the atherosclerotic plaques. Quantitative analysis of the OCT signals allowed in situ determination of the intrinsic optical attenuation coefficient of atherosclerotic tissue components within regions of interest, which can further help to discriminate the plaque and arterial wall components.
Original language | English |
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Pages | 11-17 |
Number of pages | 7 |
DOIs | |
Publication status | Published - 2005 |
Event | Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States Duration: 23 Jan 2005 → 26 Jan 2005 |
Conference
Conference | Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX |
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Country/Territory | United States |
City | San Jose, CA |
Period | 23/01/2005 → 26/01/2005 |