Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

D. Bottai; M. di Luca; L. Majlessi; W. Frigui; R. Simeone; F. Sayes; W. Bitter; M.J. Brennan; C. Leclerc; G. Batoni; M. Campa; R. Brosch; S. Esin

doi:https://doi.org/10.1111/j.1365-2958.2012.08001.x

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

D. Bottai, M. di Luca, L. Majlessi, W. Frigui, R. Simeone, F. Sayes, W. Bitter, M.J. Brennan, C. Leclerc, G. Batoni, M. Campa, R. Brosch, S. Esin

Medical Microbiology and Infection Prevention (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

155 Citations (Scopus)

Abstract

The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA

Original language	English
Pages (from-to)	1195-1209
Number of pages	15
Journal	Molecular Microbiology
Volume	83
Issue number	6
Early online date	20 Feb 2012
DOIs	https://doi.org/10.1111/j.1365-2958.2012.08001.x
Publication status	Published - Mar 2012

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Bottai, D., di Luca, M., Majlessi, L., Frigui, W., Simeone, R., Sayes, F., Bitter, W., Brennan, M. J., Leclerc, C., Batoni, G., Campa, M., Brosch, R., & Esin, S. (2012). Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Molecular Microbiology, 83(6), 1195-1209. https://doi.org/10.1111/j.1365-2958.2012.08001.x

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title = "Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.",

abstract = "The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA",

author = "D. Bottai and {di Luca}, M. and L. Majlessi and W. Frigui and R. Simeone and F. Sayes and W. Bitter and M.J. Brennan and C. Leclerc and G. Batoni and M. Campa and R. Brosch and S. Esin",

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Bottai, D, di Luca, M, Majlessi, L, Frigui, W, Simeone, R, Sayes, F, Bitter, W, Brennan, MJ, Leclerc, C, Batoni, G, Campa, M, Brosch, R & Esin, S 2012, 'Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.', Molecular Microbiology, vol. 83, no. 6, pp. 1195-1209. https://doi.org/10.1111/j.1365-2958.2012.08001.x

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T1 - Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

AU - Bottai, D.

AU - di Luca, M.

AU - Majlessi, L.

AU - Frigui, W.

AU - Simeone, R.

AU - Sayes, F.

AU - Bitter, W.

AU - Brennan, M.J.

AU - Leclerc, C.

AU - Batoni, G.

AU - Campa, M.

AU - Brosch, R.

AU - Esin, S.

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N2 - The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA

AB - The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA

U2 - https://doi.org/10.1111/j.1365-2958.2012.08001.x

DO - https://doi.org/10.1111/j.1365-2958.2012.08001.x

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