Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis

Premika S. W. Boedhoe; Lianne Schmaal; Yoshinari Abe; Stephanie H. Ameis; Paul D. Arnold; Marcelo C. Batistuzzo; Francesco Benedetti; Jan C. Beucke; Irene Bollettini; Anushree Bose; Silvia Brem; Anna Calvo; Yuqi Cheng; Kang Ik K. Cho; Sara Dallaspezia; Damiaan Denys; Kate D. Fitzgerald; Jean-Paul Fouche; Monica Gimenez; Patricia Gruner; Gregory L. Hanna; Derrek P. Hibar; Marcelo Q. Hoexter; Hao Hu; Chaim Huyser; Keisuke Ikari; Neda Jahanshad; Norbert Kathmann; Christian Kaufmann; Kathrin Koch; Jun Soo Kwon; Luisa Lazaro; Yanni Liu; Christine Lochner; Rachel Marsh; Ignacio Martinez-Zalacain; David Mataix-Cols; Jose M. Menchon; Luciano Minuzzi; Takashi Nakamae; Tomohiro Nakao; Janardhanan C. Narayanaswamy; Fabrizio Piras; Federica Piras; Christopher Pittenger; Y. C. Janardhan Reddy; Joao R. Sato; H. Blair Simpson; Odile A. van den Heuvel; ENIGMA OCD Working Group; AUTHOR GROUP; Noam Soreni; Guido A. van Wingen

doi:https://doi.org/10.1176/appi.ajp.2016.16020201

Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis

Premika S. W. Boedhoe, Lianne Schmaal, Yoshinari Abe, Stephanie H. Ameis, Paul D. Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Kate D. Fitzgerald, Jean-Paul Fouche, Monica Gimenez, Patricia GrunerGregory L. Hanna, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Neda Jahanshad, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Yanni Liu, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Jose M. Menchon, Luciano Minuzzi, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Joao R. Sato, H. Blair Simpson, Odile A. van den Heuvel, ENIGMA OCD Working Group, AUTHOR GROUP, Noam Soreni, Guido A. van Wingen

Research output: Contribution to journal › Article › Academic › peer-review

240 Citations (Scopus)

Abstract

Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide. T1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful

Original language	English
Pages (from-to)	60-69
Journal	American Journal of Psychiatry
Volume	174
Issue number	1
Early online date	2016
DOIs	https://doi.org/10.1176/appi.ajp.2016.16020201
Publication status	Published - Jan 2017

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https://doi.org/10.1176/appi.ajp.2016.16020201

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Boedhoe, P. S. W., Schmaal, L., Abe, Y., Ameis, S. H., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Calvo, A., Cheng, Y., Cho, K. I. K., Dallaspezia, S., Denys, D., Fitzgerald, K. D., Fouche, J.-P., Gimenez, M., ... van Wingen, G. A. (2017). Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal of Psychiatry, 174(1), 60-69. https://doi.org/10.1176/appi.ajp.2016.16020201

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title = "Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis",

abstract = "Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide. T1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful",

author = "Boedhoe, {Premika S. W.} and Lianne Schmaal and Yoshinari Abe and Ameis, {Stephanie H.} and Arnold, {Paul D.} and Batistuzzo, {Marcelo C.} and Francesco Benedetti and Beucke, {Jan C.} and Irene Bollettini and Anushree Bose and Silvia Brem and Anna Calvo and Yuqi Cheng and Cho, {Kang Ik K.} and Sara Dallaspezia and Damiaan Denys and Fitzgerald, {Kate D.} and Jean-Paul Fouche and Monica Gimenez and Patricia Gruner and Hanna, {Gregory L.} and Hibar, {Derrek P.} and Hoexter, {Marcelo Q.} and Hao Hu and Chaim Huyser and Keisuke Ikari and Neda Jahanshad and Norbert Kathmann and Christian Kaufmann and Kathrin Koch and Kwon, {Jun Soo} and Luisa Lazaro and Yanni Liu and Christine Lochner and Rachel Marsh and Ignacio Martinez-Zalacain and David Mataix-Cols and Menchon, {Jose M.} and Luciano Minuzzi and Takashi Nakamae and Tomohiro Nakao and Narayanaswamy, {Janardhanan C.} and Fabrizio Piras and Federica Piras and Christopher Pittenger and Reddy, {Y. C. Janardhan} and Sato, {Joao R.} and Simpson, {H. Blair} and {van den Heuvel}, {Odile A.} and {ENIGMA OCD Working Group} and {van der Werf}, YD and {AUTHOR GROUP} and Noam Soreni and {van Wingen}, {Guido A.}",

year = "2017",

month = jan,

doi = "https://doi.org/10.1176/appi.ajp.2016.16020201",

language = "English",

volume = "174",

pages = "60--69",

journal = "American Journal of Psychiatry",

issn = "0002-953X",

publisher = "American Psychiatric Association",

number = "1",

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Boedhoe, PSW, Schmaal, L, Abe, Y, Ameis, SH, Arnold, PD, Batistuzzo, MC, Benedetti, F, Beucke, JC, Bollettini, I, Bose, A, Brem, S, Calvo, A, Cheng, Y, Cho, KIK, Dallaspezia, S, Denys, D, Fitzgerald, KD, Fouche, J-P, Gimenez, M, Gruner, P, Hanna, GL, Hibar, DP, Hoexter, MQ, Hu, H, Huyser, C, Ikari, K, Jahanshad, N, Kathmann, N, Kaufmann, C, Koch, K, Kwon, JS, Lazaro, L, Liu, Y, Lochner, C, Marsh, R, Martinez-Zalacain, I, Mataix-Cols, D, Menchon, JM, Minuzzi, L, Nakamae, T, Nakao, T, Narayanaswamy, JC, Piras, F, Piras, F, Pittenger, C, Reddy, YCJ, Sato, JR, Simpson, HB, van den Heuvel, OA, ENIGMA OCD Working Group, AUTHOR GROUP, Soreni, N & van Wingen, GA 2017, 'Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis', American Journal of Psychiatry, vol. 174, no. 1, pp. 60-69. https://doi.org/10.1176/appi.ajp.2016.16020201

TY - JOUR

T1 - Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis

AU - Boedhoe, Premika S. W.

AU - Schmaal, Lianne

AU - Abe, Yoshinari

AU - Ameis, Stephanie H.

AU - Arnold, Paul D.

AU - Batistuzzo, Marcelo C.

AU - Benedetti, Francesco

AU - Beucke, Jan C.

AU - Bollettini, Irene

AU - Bose, Anushree

AU - Brem, Silvia

AU - Calvo, Anna

AU - Cheng, Yuqi

AU - Cho, Kang Ik K.

AU - Dallaspezia, Sara

AU - Denys, Damiaan

AU - Fitzgerald, Kate D.

AU - Fouche, Jean-Paul

AU - Gimenez, Monica

AU - Gruner, Patricia

AU - Hanna, Gregory L.

AU - Hibar, Derrek P.

AU - Hoexter, Marcelo Q.

AU - Hu, Hao

AU - Huyser, Chaim

AU - Ikari, Keisuke

AU - Jahanshad, Neda

AU - Kathmann, Norbert

AU - Kaufmann, Christian

AU - Koch, Kathrin

AU - Kwon, Jun Soo

AU - Lazaro, Luisa

AU - Liu, Yanni

AU - Lochner, Christine

AU - Marsh, Rachel

AU - Martinez-Zalacain, Ignacio

AU - Mataix-Cols, David

AU - Menchon, Jose M.

AU - Minuzzi, Luciano

AU - Nakamae, Takashi

AU - Nakao, Tomohiro

AU - Narayanaswamy, Janardhanan C.

AU - Piras, Fabrizio

AU - Piras, Federica

AU - Pittenger, Christopher

AU - Reddy, Y. C. Janardhan

AU - Sato, Joao R.

AU - Simpson, H. Blair

AU - van den Heuvel, Odile A.

AU - ENIGMA OCD Working Group

AU - van der Werf, YD

AU - AUTHOR GROUP

AU - Soreni, Noam

AU - van Wingen, Guido A.

PY - 2017/1

Y1 - 2017/1

N2 - Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide. T1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful

AB - Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide. T1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful

U2 - https://doi.org/10.1176/appi.ajp.2016.16020201

DO - https://doi.org/10.1176/appi.ajp.2016.16020201

M3 - Article

C2 - 27609241

SN - 0002-953X

VL - 174

SP - 60

EP - 69

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 1

ER -