TY - JOUR
T1 - Do Polymorphisms Predict Hypnotherapy Response in Children With Functional Abdominal Pain Disorders
T2 - An Explorative Study
AU - de Bruijn, Clara M. A.
AU - Hovy, Stefan W.
AU - Tromp, Ellen
AU - Benninga, Marc A.
AU - Hall, Kathryn T.
AU - Vlieger, Arine M.
N1 - Funding Information: Sources of Funding: This study was supported by St Antonius Hospital Research Foundation. Publisher Copyright: © 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/10/1
Y1 - 2023/10/1
N2 - Genetic variations, in specific COMT , OPRM1 , and MAO-A polymorphisms, have been associated with hypnotizability in adults. The aim of this exploratory study was to investigate whether these polymorphisms are also associated with response to hypnotherapy (HT) in children. Patients (8-18 years, n = 260) diagnosed with a functional abdominal pain disorder (FAPD) from a previous trial assessing HT efficacy were approached for participation and 144 agreed to collect a buccal sample. Primary aim was to explore the association between COMT , OPRM1 , and MAO-A polymorphisms with treatment success (TS) after 3-month HT. Additionally, associations between these polymorphisms and adequate relief, anxiety, depression, quality of life, somatization, hypnotic susceptibility, expectations, pain beliefs, and coping strategies were evaluated. Participants with different variations of COMT , MAO-A , and OPRM1 achieved similar TS levels ( P > 0.05). No associations were found between these polymorphisms and secondary outcomes. This suggest that in pediatric patients with FAPDs, COMT , OPRM1 , and MAO-A polymorphisms do not predict HT response.
AB - Genetic variations, in specific COMT , OPRM1 , and MAO-A polymorphisms, have been associated with hypnotizability in adults. The aim of this exploratory study was to investigate whether these polymorphisms are also associated with response to hypnotherapy (HT) in children. Patients (8-18 years, n = 260) diagnosed with a functional abdominal pain disorder (FAPD) from a previous trial assessing HT efficacy were approached for participation and 144 agreed to collect a buccal sample. Primary aim was to explore the association between COMT , OPRM1 , and MAO-A polymorphisms with treatment success (TS) after 3-month HT. Additionally, associations between these polymorphisms and adequate relief, anxiety, depression, quality of life, somatization, hypnotic susceptibility, expectations, pain beliefs, and coping strategies were evaluated. Participants with different variations of COMT , MAO-A , and OPRM1 achieved similar TS levels ( P > 0.05). No associations were found between these polymorphisms and secondary outcomes. This suggest that in pediatric patients with FAPDs, COMT , OPRM1 , and MAO-A polymorphisms do not predict HT response.
KW - COMT
KW - MAO-A
KW - OPRM1
KW - functional abdominal pain disorders
KW - hypnotherapy
KW - pediatrics
KW - polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=85171901687&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/MPG.0000000000003895
DO - https://doi.org/10.1097/MPG.0000000000003895
M3 - Article
C2 - 37490618
SN - 0277-2116
VL - 77
SP - 486
EP - 490
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 4
ER -