TY - JOUR
T1 - Does myocardial fibrosis hinder contractile function and perfusion in idopathic dilated cardiomyopathy ? PET and MR imaging study
AU - Knaapen, P.
AU - Gotte, M.J.W.
AU - Paulus, W.J.S.
AU - Zwanenburg, J.J.M.
AU - Dijkmans, P.A.
AU - Boellaard, R.
AU - Marcus, J.T.
AU - Twisk, J.W.
AU - Visser, C.A.
AU - van Rossum, A.C.
AU - Lammertsma, A.A.
AU - Visser, F.C.
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Purpose: To prospectively evaluate, by using positron emission tomography (PET) and magnetic resonance (MR) imaging, the interrelationships between regional myocardial fibrosis, perfusion, and contractile function in patients with idiopathic dilated cardiomyopathy (DCM). Materials and Methods: The study protocol was approved by the hospital ethics committee, and all subjects gave written informed consent. Sixteen patients with idiopathic DCM (mean age, 54 years ± 11 [standard deviation]; nine men) and six healthy control subjects (mean age, 28 years ± 2; five men) were examined with PET and MR tissue tagging. Oxygen 15-labeled water and carbon monoxide were used as tracers at PET to assess myocardial blood flow (MBP) and the perfusable tissue index (PTI), which is inversely related to fibrosis. MBF was determined at rest and during pharmacologically induced hyperemia. Maximum circumferential shortening (E
AB - Purpose: To prospectively evaluate, by using positron emission tomography (PET) and magnetic resonance (MR) imaging, the interrelationships between regional myocardial fibrosis, perfusion, and contractile function in patients with idiopathic dilated cardiomyopathy (DCM). Materials and Methods: The study protocol was approved by the hospital ethics committee, and all subjects gave written informed consent. Sixteen patients with idiopathic DCM (mean age, 54 years ± 11 [standard deviation]; nine men) and six healthy control subjects (mean age, 28 years ± 2; five men) were examined with PET and MR tissue tagging. Oxygen 15-labeled water and carbon monoxide were used as tracers at PET to assess myocardial blood flow (MBP) and the perfusable tissue index (PTI), which is inversely related to fibrosis. MBF was determined at rest and during pharmacologically induced hyperemia. Maximum circumferential shortening (E
UR - http://www.scopus.com/inward/record.url?scp=33746220390&partnerID=8YFLogxK
U2 - https://doi.org/10.1148/radiol.2402051038
DO - https://doi.org/10.1148/radiol.2402051038
M3 - Article
C2 - 16864667
SN - 0033-8419
VL - 240
SP - 380
EP - 388
JO - Radiology
JF - Radiology
IS - 2
ER -