TY - JOUR
T1 - Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in rats.
AU - Loos, M
AU - Pattij, T
AU - Janssen, MC
AU - Counotte, DS
AU - Schoffelmeer, AN
AU - Smit, AB
AU - Spijker, S
AU - van, Gaalen MM
AU - van Gaalen, M.M.
PY - 2010/5
Y1 - 2010/5
N2 - A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D1, the dopamine receptor D5 and calcyon. Local mPFC infusions of the D
AB - A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D1, the dopamine receptor D5 and calcyon. Local mPFC infusions of the D
UR - http://europepmc.org/abstract/med/19690230
U2 - https://doi.org/10.1093/cercor/bhp167
DO - https://doi.org/10.1093/cercor/bhp167
M3 - Article
C2 - 19690230
SN - 1047-3211
VL - 20
SP - 1064
EP - 1070
JO - Cerebral cortex (New York, N.Y. : 1991)
JF - Cerebral cortex (New York, N.Y. : 1991)
IS - 5
ER -
