TY - JOUR
T1 - Double Trouble
T2 - A Case Series on Concomitant Genetic Aberrations in NSCLC
AU - Van Der Steen, Nele
AU - Mentens, Yves
AU - Ramael, Marc
AU - Leon, Leticia G.
AU - Germonpré, Paul
AU - Ferri, Jose
AU - Gandara, David R.
AU - Giovannetti, Elisa
AU - Peters, Godefridus J.
AU - Pauwels, Patrick
AU - Rolfo, Christian
PY - 2018/1
Y1 - 2018/1
N2 - Several oncogenic drivers have been identified in non-small cell lung cancer. Targeted therapies for these aberrations have already been successfully developed and implemented in clinical practice. Owing to improved sensitivity in genetic testing, more and more tumors with multiple driver mutations are identified, resulting in dilemmas for treating physicians whether and which targeted therapy to use. In this case series, we provide an overview of patients with intrinsic double mutations in oncogenic drivers and their reported response to targeted therapies, with a focus on epidermal growth factor receptor, anaplastic lymphoma kinase, cMET, and Kirsten rat sarcoma viral oncogene. We also include an unpublished case report on a patient with an epidermal growth factor receptor L858R and cMET exon 14 skipping.
AB - Several oncogenic drivers have been identified in non-small cell lung cancer. Targeted therapies for these aberrations have already been successfully developed and implemented in clinical practice. Owing to improved sensitivity in genetic testing, more and more tumors with multiple driver mutations are identified, resulting in dilemmas for treating physicians whether and which targeted therapy to use. In this case series, we provide an overview of patients with intrinsic double mutations in oncogenic drivers and their reported response to targeted therapies, with a focus on epidermal growth factor receptor, anaplastic lymphoma kinase, cMET, and Kirsten rat sarcoma viral oncogene. We also include an unpublished case report on a patient with an epidermal growth factor receptor L858R and cMET exon 14 skipping.
KW - ALK
KW - CMET
KW - EGFR
KW - KRAS
KW - Non-small cell lung cancer
UR - http://www.scopus.com/inward/record.url?scp=85026251377&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cllc.2017.06.010
DO - https://doi.org/10.1016/j.cllc.2017.06.010
M3 - Article
C2 - 28757336
SN - 1525-7304
VL - 19
SP - 35
EP - 41
JO - Clinical Lung Cancer
JF - Clinical Lung Cancer
IS - 1
ER -