Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

R. H. Hoek; S. R. Ruuls; C. A. Murphy; G. J. Wright; R. Goddard; S. M. Zurawski; B. Blom; M. E. Homola; W. J. Streit; M. H. Brown; A. N. Barclay; J. D. Sedgwick

doi:https://doi.org/10.1126/science.290.5497.1768

Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

R. H. Hoek, S. R. Ruuls, C. A. Murphy, G. J. Wright, R. Goddard, S. M. Zurawski, B. Blom, M. E. Homola, W. J. Streit, M. H. Brown, A. N. Barclay, J. D. Sedgwick

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871 Citations (Scopus)

Abstract

OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells, including brain microglia, exhibited an activated phenotype and were more numerous. Upon facial nerve transection, damaged CD200-deficient neurons elicited an accelerated microglial response. Lack of CD200 resulted in a more rapid onset of experimental autoimmune encephalomyelitis (EAE). Outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis (CIA) in mice normally resistant to this disease. Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage.

Original language	English
Pages (from-to)	1768-1771
Number of pages	4
Journal	Science
Volume	290
Issue number	5497
DOIs	https://doi.org/10.1126/science.290.5497.1768
Publication status	Published - 1 Dec 2000

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title = "Down-regulation of the macrophage lineage through interaction with OX2 (CD200)",

abstract = "OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells, including brain microglia, exhibited an activated phenotype and were more numerous. Upon facial nerve transection, damaged CD200-deficient neurons elicited an accelerated microglial response. Lack of CD200 resulted in a more rapid onset of experimental autoimmune encephalomyelitis (EAE). Outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis (CIA) in mice normally resistant to this disease. Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage.",

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T1 - Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

AU - Hoek, R. H.

AU - Ruuls, S. R.

AU - Murphy, C. A.

AU - Wright, G. J.

AU - Goddard, R.

AU - Zurawski, S. M.

AU - Blom, B.

AU - Homola, M. E.

AU - Streit, W. J.

AU - Brown, M. H.

AU - Barclay, A. N.

AU - Sedgwick, J. D.

PY - 2000/12/1

Y1 - 2000/12/1

N2 - OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells, including brain microglia, exhibited an activated phenotype and were more numerous. Upon facial nerve transection, damaged CD200-deficient neurons elicited an accelerated microglial response. Lack of CD200 resulted in a more rapid onset of experimental autoimmune encephalomyelitis (EAE). Outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis (CIA) in mice normally resistant to this disease. Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage.

AB - OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells, including brain microglia, exhibited an activated phenotype and were more numerous. Upon facial nerve transection, damaged CD200-deficient neurons elicited an accelerated microglial response. Lack of CD200 resulted in a more rapid onset of experimental autoimmune encephalomyelitis (EAE). Outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis (CIA) in mice normally resistant to this disease. Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage.

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Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

Abstract

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