TY - JOUR
T1 - Drug therapy in continuous ambulatory peritoneal dialysis patients
AU - Janknegt, R.
AU - Koelman, J. H.
PY - 1987
Y1 - 1987
N2 - Transport of solutes across the peritoneal membrane in continuous ambulatory peritoneal dialysis (CAPD) is determined by patient-related factors (concentration gradient, membrane surface area, blood flow and membrane permeability) and by drug-related factors (charge on the molecule, protein binding, molecular weight, lipophilicity). On the basis of the chemical properties of a drug a prediction of the peritoneal clearance rate in CAPD patients is given, by the formula CLCAPD = 75 square root free fraction/molecular weight. The implications of this formula are discussed. It is concluded that usually it is not necessary to change the dose as compared with end-stage renal disease patients who are not treated with CAPD
AB - Transport of solutes across the peritoneal membrane in continuous ambulatory peritoneal dialysis (CAPD) is determined by patient-related factors (concentration gradient, membrane surface area, blood flow and membrane permeability) and by drug-related factors (charge on the molecule, protein binding, molecular weight, lipophilicity). On the basis of the chemical properties of a drug a prediction of the peritoneal clearance rate in CAPD patients is given, by the formula CLCAPD = 75 square root free fraction/molecular weight. The implications of this formula are discussed. It is concluded that usually it is not necessary to change the dose as compared with end-stage renal disease patients who are not treated with CAPD
U2 - https://doi.org/10.1007/BF01960744
DO - https://doi.org/10.1007/BF01960744
M3 - Article
C2 - 3295759
SN - 0167-6555
VL - 9
SP - 104
EP - 109
JO - Pharmaceutisch weekblad. Scientific edition
JF - Pharmaceutisch weekblad. Scientific edition
IS - 2
ER -