Dye-Based Chromoendoscopy in Patients With Lynch Syndrome: An Individual Patient Data Meta-Analysis of Randomized Trials

Britt B S L Houwen; Nahid Mostafavi; Jasper L A Vleugels; Robert Hüneburg; Christof Lamberti; Liseth Rivero-Sánchez; María Pellisé; Elena M Stoffel; Sapna Syngal; Jasmijn F Haanstra; Jan J Koornstra; Evelien Dekker; Yark Hazewinkel

doi:https://doi.org/10.14309/ajg.0000000000001138

Dye-Based Chromoendoscopy in Patients With Lynch Syndrome: An Individual Patient Data Meta-Analysis of Randomized Trials

Britt B S L Houwen, Nahid Mostafavi, Jasper L A Vleugels, Robert Hüneburg, Christof Lamberti, Liseth Rivero-Sánchez, María Pellisé, Elena M Stoffel, Sapna Syngal, Jasmijn F Haanstra, Jan J Koornstra, Evelien Dekker, Yark Hazewinkel

Research output: Contribution to journal › Review article › Academic › peer-review

6 Citations (Scopus)

Abstract

INTRODUCTION: The additional diagnostic value of dye-based chromoendosocpy (CE) for surveillance of patients with Lynch syndrome is subject of debate.

METHODS: To clarify this debate, we performed an individual patient data meta-analysis of randomized studies that compared CE with WLE for the detection of adenomas in patients with Lynch syndrome.

RESULTS: Three randomized studies comprising 533 patients were included. The adenoma detection rate was 74/265 (28%) in patients randomized to WLE compared with 83/266 (31%) in patients randomized to CE (odds ratio 1.17; 95% confidence interval 0.81-1.70).

DISCUSSION: Based on low-quality evidence, CE showed no apparent increase in adenoma detection compared to WLE during surveillance of patients with Lynch syndrome.

Original language	English
Pages (from-to)	825-828
Number of pages	4
Journal	The American journal of gastroenterology
Volume	116
Issue number	4
DOIs	https://doi.org/10.14309/ajg.0000000000001138
Publication status	Published - 1 Apr 2021

Keywords

Colonoscopy/methods
Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis
Humans
Randomized Controlled Trials as Topic

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Houwen, B. B. S. L., Mostafavi, N., Vleugels, J. L. A., Hüneburg, R., Lamberti, C., Rivero-Sánchez, L., Pellisé, M., Stoffel, E. M., Syngal, S., Haanstra, J. F., Koornstra, J. J., Dekker, E., & Hazewinkel, Y. (2021). Dye-Based Chromoendoscopy in Patients With Lynch Syndrome: An Individual Patient Data Meta-Analysis of Randomized Trials. The American journal of gastroenterology, 116(4), 825-828. https://doi.org/10.14309/ajg.0000000000001138

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title = "Dye-Based Chromoendoscopy in Patients With Lynch Syndrome: An Individual Patient Data Meta-Analysis of Randomized Trials",

abstract = "INTRODUCTION: The additional diagnostic value of dye-based chromoendosocpy (CE) for surveillance of patients with Lynch syndrome is subject of debate.METHODS: To clarify this debate, we performed an individual patient data meta-analysis of randomized studies that compared CE with WLE for the detection of adenomas in patients with Lynch syndrome.RESULTS: Three randomized studies comprising 533 patients were included. The adenoma detection rate was 74/265 (28%) in patients randomized to WLE compared with 83/266 (31%) in patients randomized to CE (odds ratio 1.17; 95% confidence interval 0.81-1.70).DISCUSSION: Based on low-quality evidence, CE showed no apparent increase in adenoma detection compared to WLE during surveillance of patients with Lynch syndrome.",

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Houwen, BBSL, Mostafavi, N, Vleugels, JLA, Hüneburg, R, Lamberti, C, Rivero-Sánchez, L, Pellisé, M, Stoffel, EM, Syngal, S, Haanstra, JF, Koornstra, JJ, Dekker, E & Hazewinkel, Y 2021, 'Dye-Based Chromoendoscopy in Patients With Lynch Syndrome: An Individual Patient Data Meta-Analysis of Randomized Trials', The American journal of gastroenterology, vol. 116, no. 4, pp. 825-828. https://doi.org/10.14309/ajg.0000000000001138

TY - JOUR

T1 - Dye-Based Chromoendoscopy in Patients With Lynch Syndrome

T2 - An Individual Patient Data Meta-Analysis of Randomized Trials

AU - Houwen, Britt B S L

AU - Mostafavi, Nahid

AU - Vleugels, Jasper L A

AU - Hüneburg, Robert

AU - Lamberti, Christof

AU - Rivero-Sánchez, Liseth

AU - Pellisé, María

AU - Stoffel, Elena M

AU - Syngal, Sapna

AU - Haanstra, Jasmijn F

AU - Koornstra, Jan J

AU - Dekker, Evelien

AU - Hazewinkel, Yark

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2021/4/1

Y1 - 2021/4/1

N2 - INTRODUCTION: The additional diagnostic value of dye-based chromoendosocpy (CE) for surveillance of patients with Lynch syndrome is subject of debate.METHODS: To clarify this debate, we performed an individual patient data meta-analysis of randomized studies that compared CE with WLE for the detection of adenomas in patients with Lynch syndrome.RESULTS: Three randomized studies comprising 533 patients were included. The adenoma detection rate was 74/265 (28%) in patients randomized to WLE compared with 83/266 (31%) in patients randomized to CE (odds ratio 1.17; 95% confidence interval 0.81-1.70).DISCUSSION: Based on low-quality evidence, CE showed no apparent increase in adenoma detection compared to WLE during surveillance of patients with Lynch syndrome.

AB - INTRODUCTION: The additional diagnostic value of dye-based chromoendosocpy (CE) for surveillance of patients with Lynch syndrome is subject of debate.METHODS: To clarify this debate, we performed an individual patient data meta-analysis of randomized studies that compared CE with WLE for the detection of adenomas in patients with Lynch syndrome.RESULTS: Three randomized studies comprising 533 patients were included. The adenoma detection rate was 74/265 (28%) in patients randomized to WLE compared with 83/266 (31%) in patients randomized to CE (odds ratio 1.17; 95% confidence interval 0.81-1.70).DISCUSSION: Based on low-quality evidence, CE showed no apparent increase in adenoma detection compared to WLE during surveillance of patients with Lynch syndrome.

KW - Colonoscopy/methods

KW - Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis

KW - Humans

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DO - https://doi.org/10.14309/ajg.0000000000001138

M3 - Review article

C2 - 33982955

SN - 0002-9270

VL - 116

SP - 825

EP - 828

JO - The American journal of gastroenterology

JF - The American journal of gastroenterology

IS - 4

ER -

Dye-Based Chromoendoscopy in Patients With Lynch Syndrome: An Individual Patient Data Meta-Analysis of Randomized Trials

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