TY - JOUR
T1 - Early-life growth of preterm infants and its impact on neurodevelopment
AU - Ruys, Charlotte A.
AU - Hollanders, Jonneke J.
AU - Bröring, Tinka
AU - van Schie, Petra E. M.
AU - van der Pal, Sylvia M.
AU - van de Lagemaat, Monique
AU - Lafeber, Harrie N.
AU - Rotteveel, Joost
AU - Finken, Martijn J. J.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Background: Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time. Methods: We studied two cohorts of preterm-born children (gestational age ≤32 weeks and/or birth weight ≤1500 g) from 1983 (n = 708) and 2003–2006 (n = 138), respectively. We distinguished four early-life growth patterns at 3 months corrected age: appropriate for gestational age (AGA) with or without growth restriction (AGA GR+/AGA GR−), and small for gestational age (SGA) with or without catch-up growth (SGA CUG+/SGA CUG−). Intelligence quotient (IQ), neuromotor function, and behavior were assessed at ages 19 and 8 years, respectively, for the cohorts. Results: In the 2003–2006 cohort, less children had early-life GR. In both cohorts, SGA CUG− subjects had unfavorable growth trajectories and neurodevelopmental outcomes (IQ β −6.5, 95% confidence interval (CI) −9.8; −3.2, P < 0.001; neuromotor score β −1.9%, 95% CI −3.2; −0.6, P = 0.005), while SGA CUG+ subjects were comparable to adequately grown subjects. Conclusion: Although the incidence of adverse growth patterns decreased between the cohorts, possibly indicating improvements in care over time, the impact of these growth patterns on neurodevelopmental outcomes was not significantly different. Achieving adequate early-life growth may be crucial for improving neurodevelopmental outcomes, especially for preterms born SGA.
AB - Background: Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time. Methods: We studied two cohorts of preterm-born children (gestational age ≤32 weeks and/or birth weight ≤1500 g) from 1983 (n = 708) and 2003–2006 (n = 138), respectively. We distinguished four early-life growth patterns at 3 months corrected age: appropriate for gestational age (AGA) with or without growth restriction (AGA GR+/AGA GR−), and small for gestational age (SGA) with or without catch-up growth (SGA CUG+/SGA CUG−). Intelligence quotient (IQ), neuromotor function, and behavior were assessed at ages 19 and 8 years, respectively, for the cohorts. Results: In the 2003–2006 cohort, less children had early-life GR. In both cohorts, SGA CUG− subjects had unfavorable growth trajectories and neurodevelopmental outcomes (IQ β −6.5, 95% confidence interval (CI) −9.8; −3.2, P < 0.001; neuromotor score β −1.9%, 95% CI −3.2; −0.6, P = 0.005), while SGA CUG+ subjects were comparable to adequately grown subjects. Conclusion: Although the incidence of adverse growth patterns decreased between the cohorts, possibly indicating improvements in care over time, the impact of these growth patterns on neurodevelopmental outcomes was not significantly different. Achieving adequate early-life growth may be crucial for improving neurodevelopmental outcomes, especially for preterms born SGA.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052956421&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30140070
U2 - https://doi.org/10.1038/s41390-018-0139-0
DO - https://doi.org/10.1038/s41390-018-0139-0
M3 - Article
C2 - 30140070
SN - 0031-3998
VL - 85
SP - 283
EP - 292
JO - Pediatric Research
JF - Pediatric Research
IS - 3
ER -