TY - JOUR
T1 - Early loss of peritubular capillaries after kidney transplantation
AU - Steegh, Floortje M. E. G.
AU - Gelens, Marielle A. C. J.
AU - Nieman, Fred H. M.
AU - van Hooff, Johannes P.
AU - Cleutjens, Jack P. M.
AU - van Suylen, Robert Jan
AU - Daemen, Mat J. A. P.
AU - van Heurn, Ernst L. W.
AU - Christiaans, Maarten H. L.
AU - Peutz-Kootstra, Carine J.
PY - 2011
Y1 - 2011
N2 - Inflammation, interstitial fibrosis (IF), and tubular atrophy (TA) precede chronic transplant dysfunction, which is a major cause of renal allograft loss. There is an association between IF/TA and loss of peritubular capillaries (PTCs) in advanced renal disease, but whether PTC loss occurs in an early stage of chronic transplant dysfunction is unknown. Here, we studied PTC number, IF/TA, inflammation, and renal function in 48 patients who underwent protocol biopsies. Compared with before transplantation, there was a statistically significant loss of PTCs by 3 months after transplantation. Fewer PTCs in the 3-month biopsy correlated with high IF/TA and inflammation scores and predicted lower renal function at 1 year. Predictors of PTC loss during the first 3 months after transplantation included donor type, rejection, donor age, and the number of PTCs at the time of implantation. In conclusion, PTC loss occurs during the first 3 months after renal transplantation, associates with increased IF and TA, and predicts reduced renal function
AB - Inflammation, interstitial fibrosis (IF), and tubular atrophy (TA) precede chronic transplant dysfunction, which is a major cause of renal allograft loss. There is an association between IF/TA and loss of peritubular capillaries (PTCs) in advanced renal disease, but whether PTC loss occurs in an early stage of chronic transplant dysfunction is unknown. Here, we studied PTC number, IF/TA, inflammation, and renal function in 48 patients who underwent protocol biopsies. Compared with before transplantation, there was a statistically significant loss of PTCs by 3 months after transplantation. Fewer PTCs in the 3-month biopsy correlated with high IF/TA and inflammation scores and predicted lower renal function at 1 year. Predictors of PTC loss during the first 3 months after transplantation included donor type, rejection, donor age, and the number of PTCs at the time of implantation. In conclusion, PTC loss occurs during the first 3 months after renal transplantation, associates with increased IF and TA, and predicts reduced renal function
U2 - https://doi.org/10.1681/ASN.2010050531
DO - https://doi.org/10.1681/ASN.2010050531
M3 - Article
C2 - 21566051
SN - 1046-6673
VL - 22
SP - 1024
EP - 1029
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 6
ER -