TY - JOUR
T1 - Early Neurodegeneration in the Retina of Type 2 Diabetic Patients
AU - van Dijk, Hille W.
AU - Verbraak, Frank D.
AU - Kok, Pauline H. B.
AU - Stehouwer, Marilette
AU - Garvin, Mona K.
AU - Sonka, Milan
AU - DeVries, J. Hans
AU - Schlingemann, Reinier O.
AU - Abràmoff, Michael D.
PY - 2012
Y1 - 2012
N2 - PURPOSE. The purpose of this study was to determine whether diabetes type 2 causes thinning of retinal layers as a sign of neurodegeneration and to investigate the possible relationship between this thinning and duration of diabetes mellitus, diabetic retinopathy (DR) status, age, sex, and glycemic control (HbA1c). METHODS. Mean layer thickness was calculated for retinal layers following automated segmentation of spectral domain optical coherence tomography images of diabetic patients with no or minimal DR and compared with controls. To determine the relationship between layer thickness and diabetes duration, DR status, age, sex, and HbA1c, a multiple linear regression analysis was used. RESULTS. In the pericentral area of the macula, the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) were thinner in patients with minimal DR compared to controls (respective difference 1.9 mu m, 95% confidence interval [CI] 0.3-3.5 mu m; 5.2 mu m, 95% CI 1.0-9.3 mu m; 4.5 mu m, 95% CI 2.2-6.7 mu m). In the peripheral area of the macula, the RNFL and IPL were thinner in patients with minimal DR compared to controls (respective difference 3.2 mu m, 95% CI 0.1-6.4 mu m; 3.3 mu m, 95% CI 1.2-5.4 mu m). Multiple linear regression analysis showed DR status to be the only significant explanatory variable (R = 0.31, P = 0.03) for this retinal thinning. CONCLUSIONS. This study demonstrated thinner inner retinal layers in the macula of type 2 diabetic patients with minimal DR than in controls. These results support the concept that early DR includes a neurodegenerative component. (Invest Ophthalmol Vis Sci. 2012;53:2719-2719) DOI:10.1167/iovs.11-8997
AB - PURPOSE. The purpose of this study was to determine whether diabetes type 2 causes thinning of retinal layers as a sign of neurodegeneration and to investigate the possible relationship between this thinning and duration of diabetes mellitus, diabetic retinopathy (DR) status, age, sex, and glycemic control (HbA1c). METHODS. Mean layer thickness was calculated for retinal layers following automated segmentation of spectral domain optical coherence tomography images of diabetic patients with no or minimal DR and compared with controls. To determine the relationship between layer thickness and diabetes duration, DR status, age, sex, and HbA1c, a multiple linear regression analysis was used. RESULTS. In the pericentral area of the macula, the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) were thinner in patients with minimal DR compared to controls (respective difference 1.9 mu m, 95% confidence interval [CI] 0.3-3.5 mu m; 5.2 mu m, 95% CI 1.0-9.3 mu m; 4.5 mu m, 95% CI 2.2-6.7 mu m). In the peripheral area of the macula, the RNFL and IPL were thinner in patients with minimal DR compared to controls (respective difference 3.2 mu m, 95% CI 0.1-6.4 mu m; 3.3 mu m, 95% CI 1.2-5.4 mu m). Multiple linear regression analysis showed DR status to be the only significant explanatory variable (R = 0.31, P = 0.03) for this retinal thinning. CONCLUSIONS. This study demonstrated thinner inner retinal layers in the macula of type 2 diabetic patients with minimal DR than in controls. These results support the concept that early DR includes a neurodegenerative component. (Invest Ophthalmol Vis Sci. 2012;53:2719-2719) DOI:10.1167/iovs.11-8997
U2 - https://doi.org/10.1167/iovs.11-8997
DO - https://doi.org/10.1167/iovs.11-8997
M3 - Article
C2 - 22427582
SN - 0146-0404
VL - 53
SP - 2715
EP - 2719
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
IS - 6
ER -