TY - JOUR
T1 - Early prediction of nasal continuous positive airway pressure failure in preterm infants less than 30 weeks gestation
AU - de Jaegere, Anne P.
AU - van der Lee, Johanna H.
AU - Canté, Caroline
AU - van Kaam, Anton H.
PY - 2012
Y1 - 2012
N2 - Aim: To predict early nasal continuous positive airway pressure failure within the first 2 h after birth in preterm infants. Methods: Patient and respiratory support variables significantly associated with continuous positive airway pressure failure in the first 72 h after birth were identified in a cohort of preterm infants <30 weeks gestation. Using multivariable logistic regression analysis, risk estimates for early nasal continuous positive airway pressure failure were calculated. Results: From 182 infants included, 62(34%) failed early nasal continuous positive airway pressure. Birth weight <= 800 g, male gender and a fraction of inspired oxygen >0.25 at 1 and 2 h of age were significantly associated with early nasal continuous positive airway pressure failure. Combining these variables in a logistic regression model provided a minimal risk estimate for failure of 0.04[0.01-0.23] (female >800 g, FiO(2) <= 0.25 at 1, and 2 h) and maximal estimate of 0.92[0.44-0.99] (male <= 800 g, FiO(2) > 0.25 at 1 and 2 h). Conclusion: Combining gender, birth weight and the fraction of inspired oxygen at 1 and 2 h of age allows for a better and more individualized prediction of early nasal continuous positive airway pressure failure in preterm infants less than 30 weeks gestation
AB - Aim: To predict early nasal continuous positive airway pressure failure within the first 2 h after birth in preterm infants. Methods: Patient and respiratory support variables significantly associated with continuous positive airway pressure failure in the first 72 h after birth were identified in a cohort of preterm infants <30 weeks gestation. Using multivariable logistic regression analysis, risk estimates for early nasal continuous positive airway pressure failure were calculated. Results: From 182 infants included, 62(34%) failed early nasal continuous positive airway pressure. Birth weight <= 800 g, male gender and a fraction of inspired oxygen >0.25 at 1 and 2 h of age were significantly associated with early nasal continuous positive airway pressure failure. Combining these variables in a logistic regression model provided a minimal risk estimate for failure of 0.04[0.01-0.23] (female >800 g, FiO(2) <= 0.25 at 1, and 2 h) and maximal estimate of 0.92[0.44-0.99] (male <= 800 g, FiO(2) > 0.25 at 1 and 2 h). Conclusion: Combining gender, birth weight and the fraction of inspired oxygen at 1 and 2 h of age allows for a better and more individualized prediction of early nasal continuous positive airway pressure failure in preterm infants less than 30 weeks gestation
U2 - https://doi.org/10.1111/j.1651-2227.2011.02558.x
DO - https://doi.org/10.1111/j.1651-2227.2011.02558.x
M3 - Article
C2 - 22150698
SN - 0803-5253
VL - 101
SP - 374
EP - 379
JO - Acta paediatrica (Oslo, Norway
JF - Acta paediatrica (Oslo, Norway
IS - 4
ER -