Early treatment response in malignant lymphoma, as determined by planar fluorine-18-fluorodeoxyglucose scintigraphy

O. S. Hoekstra, G. J. Ossenkoppele, R. Golding, A. Van Lingen, G. W.M. Visser, G. J.J. Teule, P. C. Huijgens

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Clinical oncology needs flexible techniques for routine monitoring of treatment response. We therefore compared planar 18F-fluorodeoxyglucose (FDG) with a conventional gamma-camera and a special collimator to 67Ga scintigraphy in 26 patients with malignant lymphoma during chemotherapy. The scintigraphic appearance of involved sites was essentially the same with both tracers; in patients eventually achieving complete remission, tracer distribution had normalized after two courses; high uptake reflected treatment failure; faint uptake was associated with variable outcome. For (re)staging, 67Ga may be preferable (higher contrast). To document the initial response, we performed FDG scintigraphy during the first course (n = 11). Effective treatment sharply reduced metabolic tumor activity within days and prior to volume response, whereas abnormal uptake persisted in treatment failure. Planar FDG scintigraphy may be a tool to assess the potentially prognostic initial response rate, preventing overtreatment and allowing a timely switch to more aggressive therapy.

Original languageEnglish
Pages (from-to)1706-1710
Number of pages5
JournalJournal of nuclear medicine
Issue number10
Publication statusPublished - 1993

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