EBV-Positive B-Cell Proliferations of Varied Malignant Potential: 2015 SH/EAHP Workshop Report-Part 1

Yasodha Natkunam, John R Goodlad, Amy Chadburn, Daphne de Jong, Dita Gratzinger, John K C Chan, Jonathan Said, Elaine S Jaffe

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Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review B-cell proliferations of varied malignant potential associated with immunodeficiency.

Methods: The Workshop Panel reviewed all cases of B-cell hyperplasias, polymorphic B-lymphoproliferative disorders, Epstein-Barr virus (EBV)-positive mucocutaneous ulcer, and large B-cell proliferations associated with chronic inflammation and rendered consensus diagnoses. Disease definitions, boundaries with more aggressive B-cell proliferations, and association with EBV were explored.

Results: B-cell proliferations of varied malignant potential occurred in all immunodeficiency backgrounds. Presentation early in the course of immunodeficiency and in younger age groups and regression with reduction of immunosuppression were characteristic features. EBV positivity was essential for diagnosis in some hyperplasias where other specific defining features were absent.

Conclusions: This spectrum of B-cell proliferations show similarities across immunodeficiency backgrounds. Localized forms of immunodeficiency disorders arise in immunocompetent patients most likely due to chronic immune stimulation and, despite aggressive histologic features, often show indolent clinical behavior.

Original languageEnglish
Pages (from-to)129-152
Number of pages24
JournalAmerican Journal of Clinical Pathology
Issue number2
Publication statusPublished - 1 Feb 2017


  • Adult
  • Aged
  • B-Lymphocytes
  • Child
  • Child, Preschool
  • Education
  • Epstein-Barr Virus Infections
  • Female
  • Humans
  • Journal Article
  • Lymphoproliferative Disorders
  • Male
  • Middle Aged
  • Young Adult

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