Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study. Results from the anti-oxidant therapy in chronic renal insufficiency (ATIC) study

P.W. Nanayakkara, C. van Guldener, P.M. ter Wee, P.G. Scheffer, F.J. van Ittersum, J.W.R. Twisk, T. Teerlink, W. van Dorp, C.D.A. Stehouwer

Research output: Contribution to journalArticleAcademicpeer-review

100 Citations (Scopus)

Abstract

Background: Patients with chronic kidney disease have an increased risk of cardiovascular disease. Oxidative stress has been proposed to play a role in the development of cardiovascular disease among these patients. Methods:Weconducted a randomized, double-blind trial in 93 patients (Cockcroft-Gault equation: creatinine clearance, 38±15 [mean±SD] mL/min per 1.73 m
Original languageEnglish
Pages (from-to)1262-1270
Number of pages9
JournalArchives of Internal Medicine
Volume167
Issue number12
DOIs
Publication statusPublished - 25 Jun 2007

Cite this