TY - JOUR
T1 - Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome
AU - Vink, Arja Suzanne
AU - Clur, Sally-Ann B.
AU - Wilde, Arthur A. M.
AU - Blom, Nico A.
PY - 2018
Y1 - 2018
N2 - Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.
AB - Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85028383043&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/28869094
U2 - https://doi.org/10.1016/j.tcm.2017.07.012
DO - https://doi.org/10.1016/j.tcm.2017.07.012
M3 - Review article
C2 - 28869094
SN - 1050-1738
VL - 28
SP - 64
EP - 75
JO - Trends in cardiovascular medicine
JF - Trends in cardiovascular medicine
IS - 1
ER -