TY - JOUR
T1 - Effect of stent diameter in women undergoing percutaneous coronary intervention with early- and new-generation drug-eluting stents
T2 - From the WIN-DES collaboration
AU - Camaj, Anton
AU - Giustino, Gennaro
AU - Claessen, Bimmer E.
AU - Baber, Usman
AU - Power, David A.
AU - Sartori, Samantha
AU - Aquino, Melissa
AU - Stone, Gregg W.
AU - Windecker, Stephan
AU - Dangas, George
AU - Mehran, Roxana
N1 - Funding Information: Dr. Windecker has received research contracts to the institution from Abbott, Boston Scientific, Biosensors, Cordis, and Medtronic. Dr. Mehran has received institutional research grant support from The Medicines Company , Bristol-Myers Squibb , Sanofi-Aventis , Eli Lilly and Company , and AstraZeneca and consulting fees from AstraZeneca, Bayer, CSL Behring, Janssen Pharmaceuticals Inc., Merck & Co, Osprey Medical Inc., and Watermark Research Partners and serves on the advisory board of Abbott Laboratories, Boston Scientific Corporation, Covidien, Janssen Pharmaceuticals, The Medicines Company, and Sanofi-Aventis. No other disclosures were reported. Funding Information: Dr. Windecker has received research contracts to the institution from Abbott, Boston Scientific, Biosensors, Cordis, and Medtronic. Dr. Mehran has received institutional research grant support from The Medicines Company, Bristol-Myers Squibb, Sanofi-Aventis, Eli Lilly and Company, and AstraZeneca and consulting fees from AstraZeneca, Bayer, CSL Behring, Janssen Pharmaceuticals Inc., Merck & Co, Osprey Medical Inc., and Watermark Research Partners and serves on the advisory board of Abbott Laboratories, Boston Scientific Corporation, Covidien, Janssen Pharmaceuticals, The Medicines Company, and Sanofi-Aventis. No other disclosures were reported. Publisher Copyright: © 2019 Elsevier B.V.
PY - 2019/7/15
Y1 - 2019/7/15
N2 - Background: The risk of stent thrombosis (ST)or target lesion revascularization (TLR)is increased with smaller stent diameters (SD). Whether SD has a deleterious effect in women treated with early- vs. new-generation drug-eluting stents (DES)is unknown. Methods: We pooled patient-level data from 26 randomized control trials of DES. Only women treated with DES were included. Subjects were stratified according to SD: small, SD ≤ 2.75 mm; intermediate, 2.75 mm < SD ≤ 3.25 mm; and large, SD ≥ 3.25 mm. Endpoints of interest were 3-year definite ST, TLR, major adverse cardiac events (MACE: the composite of death, myocardial infarction or TLR)and death. Results: Of 6413 women, 2274 (35.0%)had a small SD, 2448 (38.0%)had an intermediate SD, and 1691 (26.0%)had a large SD. By multivariable analysis, stent diameter (per 0.25 mm decrease)was associated with an increased risk of TLR and ST, which was uniform in terms of magnitude and direction between early- and new-generation DES. There were no differences in MACE or death across groups. Conclusion: Small SD in women undergoing PCI is associated with an increased risk of definite ST and TLR, consistently with both early- and new-generation DES.
AB - Background: The risk of stent thrombosis (ST)or target lesion revascularization (TLR)is increased with smaller stent diameters (SD). Whether SD has a deleterious effect in women treated with early- vs. new-generation drug-eluting stents (DES)is unknown. Methods: We pooled patient-level data from 26 randomized control trials of DES. Only women treated with DES were included. Subjects were stratified according to SD: small, SD ≤ 2.75 mm; intermediate, 2.75 mm < SD ≤ 3.25 mm; and large, SD ≥ 3.25 mm. Endpoints of interest were 3-year definite ST, TLR, major adverse cardiac events (MACE: the composite of death, myocardial infarction or TLR)and death. Results: Of 6413 women, 2274 (35.0%)had a small SD, 2448 (38.0%)had an intermediate SD, and 1691 (26.0%)had a large SD. By multivariable analysis, stent diameter (per 0.25 mm decrease)was associated with an increased risk of TLR and ST, which was uniform in terms of magnitude and direction between early- and new-generation DES. There were no differences in MACE or death across groups. Conclusion: Small SD in women undergoing PCI is associated with an increased risk of definite ST and TLR, consistently with both early- and new-generation DES.
UR - http://www.scopus.com/inward/record.url?scp=85064166970&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ijcard.2019.03.034
DO - https://doi.org/10.1016/j.ijcard.2019.03.034
M3 - Article
C2 - 30982549
SN - 0167-5273
VL - 287
SP - 59
EP - 61
JO - International journal of cardiology
JF - International journal of cardiology
ER -