TY - JOUR
T1 - Effect of the inclusion of the metacarpophalangeal joints on the wrist magnetic resonance imaging scoring system in juvenile idiopathic arthritis
AU - van Dijkhuizen, E. H. Pieter
AU - Vanoni, Federica
AU - Magnano, Gian Michele
AU - Magnaguagno, Francesca
AU - Rosendahl, Karen
AU - van Rossum, Marion A.
AU - Martini, Alberto
AU - Malattia, Clara
PY - 2018
Y1 - 2018
N2 - Objective. To extend the magnetic resonance imaging (MRI) score for assessment of wrist synovitis in juvenile idiopathic arthritis (JIA) by inclusion of the metacarpophalangeal (MCP) joints, and to compare the metric properties of the original and the extended score. Methods. Wrist MRI of 70 patients with JIA were scored by 3 independent readers according to (1) the wrist component of the rheumatoid arthritis MRI synovitis score (comprising distal radioulnar, radiocarpal, and combined midcarpal and carpometacarpal joints); and (2) an extended score including the MCP joints. Thirty-eight patients had a 1-year MRI followup. The concordance between the readers [intraclass correlation coefficient (ICC), 95% limits of agreement (LOA), and weighted Cohen's k], correlations with clinical variables (Spearman's q), and the sensitivity to change [standardized response mean (SRM)] were calculated for both scores. Results. The interreader agreement was moderate for the original score (ICC 0.77; 95% CI 0.68-0.84) and good for the extended score (ICC 0.86; 95% CI 0.80-0.91). Using 95% LOA, the aggregate score variability was less favorable with relatively wide LOA. Weighted Cohen's k of the individual joints indicated good agreement for the original score and good to excellent agreement for the extended score. Correlations with clinical variables reflecting disease activity improved for the extended score and its SRM was higher compared to that of the original score. Conclusion. The extended score showed better reliability, construct validity, and sensitivity to change than the original. Inclusion of the MCP joints should be considered for a more accurate assessment of disease activity and treatment efficacy in JIA.
AB - Objective. To extend the magnetic resonance imaging (MRI) score for assessment of wrist synovitis in juvenile idiopathic arthritis (JIA) by inclusion of the metacarpophalangeal (MCP) joints, and to compare the metric properties of the original and the extended score. Methods. Wrist MRI of 70 patients with JIA were scored by 3 independent readers according to (1) the wrist component of the rheumatoid arthritis MRI synovitis score (comprising distal radioulnar, radiocarpal, and combined midcarpal and carpometacarpal joints); and (2) an extended score including the MCP joints. Thirty-eight patients had a 1-year MRI followup. The concordance between the readers [intraclass correlation coefficient (ICC), 95% limits of agreement (LOA), and weighted Cohen's k], correlations with clinical variables (Spearman's q), and the sensitivity to change [standardized response mean (SRM)] were calculated for both scores. Results. The interreader agreement was moderate for the original score (ICC 0.77; 95% CI 0.68-0.84) and good for the extended score (ICC 0.86; 95% CI 0.80-0.91). Using 95% LOA, the aggregate score variability was less favorable with relatively wide LOA. Weighted Cohen's k of the individual joints indicated good agreement for the original score and good to excellent agreement for the extended score. Correlations with clinical variables reflecting disease activity improved for the extended score and its SRM was higher compared to that of the original score. Conclusion. The extended score showed better reliability, construct validity, and sensitivity to change than the original. Inclusion of the MCP joints should be considered for a more accurate assessment of disease activity and treatment efficacy in JIA.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055893986&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30111639
U2 - https://doi.org/10.3899/jrheum.171246
DO - https://doi.org/10.3899/jrheum.171246
M3 - Article
C2 - 30111639
SN - 0315-162X
VL - 45
SP - 1581
EP - 1587
JO - Journal of rheumatology
JF - Journal of rheumatology
IS - 11
ER -