TY - JOUR
T1 - Effect of tumor necrosis factor in normal subjects
AU - Colman, Robert W.
AU - Rosner, Fred
AU - Van Der Poll, Tom
AU - Büller, Harry R.
AU - Ten Cate, Jan W.
AU - Hack, C. Erik
PY - 1990/11/8
Y1 - 1990/11/8
N2 - To the Editor: Considering that there is now a consensus on the central role of tumor necrosis factor in the pathogenesis of septic shock, the study by van der Poll et al. (June 7 issue),1 in which normal subjects were administered tumor necrosis factor, is both timely and important. I agree with their deduction — based on the increased levels of the activation peptide of factor X and prothrombin fragment F1+2 — that the common coagulation pathway is probably activated initially by tissue factor. However, their conclusion that the intrinsic pathway, particularly the contact system, was not activated is.
AB - To the Editor: Considering that there is now a consensus on the central role of tumor necrosis factor in the pathogenesis of septic shock, the study by van der Poll et al. (June 7 issue),1 in which normal subjects were administered tumor necrosis factor, is both timely and important. I agree with their deduction — based on the increased levels of the activation peptide of factor X and prothrombin fragment F1+2 — that the common coagulation pathway is probably activated initially by tissue factor. However, their conclusion that the intrinsic pathway, particularly the contact system, was not activated is.
UR - http://www.scopus.com/inward/record.url?scp=0025115670&partnerID=8YFLogxK
U2 - https://doi.org/10.1056/NEJM199011083231915
DO - https://doi.org/10.1056/NEJM199011083231915
M3 - Comment/Letter to the editor
C2 - 2215625
SN - 0028-4793
VL - 323
SP - 1350
EP - 1352
JO - New England journal of medicine
JF - New England journal of medicine
IS - 19
ER -