Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial

A.W. Enneman, C.M.A. Swart, J.P. van Wijngaarden, S.C. van Dijk, A.C. van der Ham, E.M. Brouwer-Brolsma, N.L. van der Zwaluw, R.A.M. Dhonukshe-Rutten, T.J.M. van der Cammen, L.C.P.G. de Groot, J. van Meurs, P. Lips, A. G. Uitterlinden, M.C. Zillikens, N.M. van Schoor, N. van der Velde, Karin M. A. Swart

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30 Citations (Scopus)


High plasma homocysteine (Hcy) levels are associated with increased osteoporotic fracture incidence. However, the mechanism remains unclear. We investigated the effect of Hcy-lowering vitamin B
Original languageEnglish
Pages (from-to)401-409
JournalCalcified tissue international
Issue number5
Publication statusPublished - 2015

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