1 Citation (Scopus)


BACKGROUND: Cognitive behavioural therapy (CBT) reduces MS-related fatigue. However, studies on the long-term effects show inconsistent findings.

OBJECTIVE: To evaluate whether a blended booster programme improves the outcome of CBT for MS-related fatigue on fatigue severity at 1-year follow-up.

METHOD: A multicentre randomized clinical trial in which 126 patients with MS were allocated to either a booster programme or no booster programme (control), after following 20-week tailored CBT for MS-related fatigue. Primary outcome was fatigue severity assessed with the Checklist Individual Strength fatigue subscale 1 year after start of treatment (T52). Mixed model analysis was performed by a statistician blinded for treatment-allocation to determine between-group differences in fatigue severity.

RESULTS: Fatigue severity at 1-year follow-up did not differ significantly between the booster ( N = 62) and control condition ( N = 64) ( B = -2.01, 95% confidence interval (CI) = -4.76 to 0.75). No significant increase in fatigue severity was found at T52 compared with directly post-treatment (T20) in both conditions ( B = 0.44, 95% CI = -0.97 to 1.85).

CONCLUSION: Effects of CBT were sustained up to 1 year in both conditions. The booster programme did not significantly improve the long-term outcome of CBT for MS-related fatigue.

TRIAL REGISTRATION: Dutch Trial Register (NTR6966), registered 18 January 2018 https://www.trialregister.nl/trial/6782.

Original languageEnglish
Pages (from-to)71-79
Number of pages9
JournalMultiple sclerosis (Houndmills, Basingstoke, England)
Issue number1
Early online date29 Nov 2023
Publication statusPublished - Jan 2024


  • MS-related fatigue
  • booster sessions
  • cognitive behavioural therapy
  • e-health
  • long-term effects
  • randomized controlled trial

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