Effectiveness of a blended booster programme for the long-term outcome of cognitive behavioural therapy for MS-related fatigue: A randomized controlled trial

Marieke de Gier; Heleen Beckerman; Jos Wr Twisk; Hans Knoop; Vincent de Groot

doi:https://doi.org/10.1177/13524585231213258

Effectiveness of a blended booster programme for the long-term outcome of cognitive behavioural therapy for MS-related fatigue: A randomized controlled trial

Marieke de Gier, Heleen Beckerman, Jos Wr Twisk, Hans Knoop, Vincent de Groot

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

BACKGROUND: Cognitive behavioural therapy (CBT) reduces MS-related fatigue. However, studies on the long-term effects show inconsistent findings.

OBJECTIVE: To evaluate whether a blended booster programme improves the outcome of CBT for MS-related fatigue on fatigue severity at 1-year follow-up.

METHOD: A multicentre randomized clinical trial in which 126 patients with MS were allocated to either a booster programme or no booster programme (control), after following 20-week tailored CBT for MS-related fatigue. Primary outcome was fatigue severity assessed with the Checklist Individual Strength fatigue subscale 1 year after start of treatment (T52). Mixed model analysis was performed by a statistician blinded for treatment-allocation to determine between-group differences in fatigue severity.

RESULTS: Fatigue severity at 1-year follow-up did not differ significantly between the booster ( N = 62) and control condition ( N = 64) ( B = -2.01, 95% confidence interval (CI) = -4.76 to 0.75). No significant increase in fatigue severity was found at T52 compared with directly post-treatment (T20) in both conditions ( B = 0.44, 95% CI = -0.97 to 1.85).

CONCLUSION: Effects of CBT were sustained up to 1 year in both conditions. The booster programme did not significantly improve the long-term outcome of CBT for MS-related fatigue.

TRIAL REGISTRATION: Dutch Trial Register (NTR6966), registered 18 January 2018 https://www.trialregister.nl/trial/6782.

Original language	English
Pages (from-to)	71-79
Number of pages	9
Journal	Multiple sclerosis (Houndmills, Basingstoke, England)
Volume	30
Issue number	1
Early online date	29 Nov 2023
DOIs	https://doi.org/10.1177/13524585231213258
Publication status	Published - Jan 2024

Keywords

MS-related fatigue
booster sessions
cognitive behavioural therapy
e-health
long-term effects
randomized controlled trial

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https://doi.org/10.1177/13524585231213258

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title = "Effectiveness of a blended booster programme for the long-term outcome of cognitive behavioural therapy for MS-related fatigue: A randomized controlled trial",

abstract = "BACKGROUND: Cognitive behavioural therapy (CBT) reduces MS-related fatigue. However, studies on the long-term effects show inconsistent findings.OBJECTIVE: To evaluate whether a blended booster programme improves the outcome of CBT for MS-related fatigue on fatigue severity at 1-year follow-up.METHOD: A multicentre randomized clinical trial in which 126 patients with MS were allocated to either a booster programme or no booster programme (control), after following 20-week tailored CBT for MS-related fatigue. Primary outcome was fatigue severity assessed with the Checklist Individual Strength fatigue subscale 1 year after start of treatment (T52). Mixed model analysis was performed by a statistician blinded for treatment-allocation to determine between-group differences in fatigue severity.RESULTS: Fatigue severity at 1-year follow-up did not differ significantly between the booster ( N = 62) and control condition ( N = 64) ( B = -2.01, 95% confidence interval (CI) = -4.76 to 0.75). No significant increase in fatigue severity was found at T52 compared with directly post-treatment (T20) in both conditions ( B = 0.44, 95% CI = -0.97 to 1.85). CONCLUSION: Effects of CBT were sustained up to 1 year in both conditions. The booster programme did not significantly improve the long-term outcome of CBT for MS-related fatigue.TRIAL REGISTRATION: Dutch Trial Register (NTR6966), registered 18 January 2018 https://www.trialregister.nl/trial/6782.",

keywords = "MS-related fatigue, booster sessions, cognitive behavioural therapy, e-health, long-term effects, randomized controlled trial",

author = "{de Gier}, Marieke and Heleen Beckerman and Twisk, {Jos Wr} and Hans Knoop and {de Groot}, Vincent",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The study was funded by the Dutch MS Research Foundation (16–937 MS). Publisher Copyright: {\textcopyright} The Author(s), 2023.",

year = "2024",

month = jan,

doi = "https://doi.org/10.1177/13524585231213258",

language = "English",

volume = "30",

pages = "71--79",

journal = "Multiple sclerosis (Houndmills, Basingstoke, England)",

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Effectiveness of a blended booster programme for the long-term outcome of cognitive behavioural therapy for MS-related fatigue: A randomized controlled trial. / de Gier, Marieke ; Beckerman, Heleen ; Twisk, Jos Wr et al.
In: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 30, No. 1, 01.2024, p. 71-79.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Effectiveness of a blended booster programme for the long-term outcome of cognitive behavioural therapy for MS-related fatigue

T2 - A randomized controlled trial

AU - de Gier, Marieke

AU - Beckerman, Heleen

AU - Twisk, Jos Wr

AU - Knoop, Hans

AU - de Groot, Vincent

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The study was funded by the Dutch MS Research Foundation (16–937 MS). Publisher Copyright: © The Author(s), 2023.

PY - 2024/1

Y1 - 2024/1

N2 - BACKGROUND: Cognitive behavioural therapy (CBT) reduces MS-related fatigue. However, studies on the long-term effects show inconsistent findings.OBJECTIVE: To evaluate whether a blended booster programme improves the outcome of CBT for MS-related fatigue on fatigue severity at 1-year follow-up.METHOD: A multicentre randomized clinical trial in which 126 patients with MS were allocated to either a booster programme or no booster programme (control), after following 20-week tailored CBT for MS-related fatigue. Primary outcome was fatigue severity assessed with the Checklist Individual Strength fatigue subscale 1 year after start of treatment (T52). Mixed model analysis was performed by a statistician blinded for treatment-allocation to determine between-group differences in fatigue severity.RESULTS: Fatigue severity at 1-year follow-up did not differ significantly between the booster ( N = 62) and control condition ( N = 64) ( B = -2.01, 95% confidence interval (CI) = -4.76 to 0.75). No significant increase in fatigue severity was found at T52 compared with directly post-treatment (T20) in both conditions ( B = 0.44, 95% CI = -0.97 to 1.85). CONCLUSION: Effects of CBT were sustained up to 1 year in both conditions. The booster programme did not significantly improve the long-term outcome of CBT for MS-related fatigue.TRIAL REGISTRATION: Dutch Trial Register (NTR6966), registered 18 January 2018 https://www.trialregister.nl/trial/6782.

AB - BACKGROUND: Cognitive behavioural therapy (CBT) reduces MS-related fatigue. However, studies on the long-term effects show inconsistent findings.OBJECTIVE: To evaluate whether a blended booster programme improves the outcome of CBT for MS-related fatigue on fatigue severity at 1-year follow-up.METHOD: A multicentre randomized clinical trial in which 126 patients with MS were allocated to either a booster programme or no booster programme (control), after following 20-week tailored CBT for MS-related fatigue. Primary outcome was fatigue severity assessed with the Checklist Individual Strength fatigue subscale 1 year after start of treatment (T52). Mixed model analysis was performed by a statistician blinded for treatment-allocation to determine between-group differences in fatigue severity.RESULTS: Fatigue severity at 1-year follow-up did not differ significantly between the booster ( N = 62) and control condition ( N = 64) ( B = -2.01, 95% confidence interval (CI) = -4.76 to 0.75). No significant increase in fatigue severity was found at T52 compared with directly post-treatment (T20) in both conditions ( B = 0.44, 95% CI = -0.97 to 1.85). CONCLUSION: Effects of CBT were sustained up to 1 year in both conditions. The booster programme did not significantly improve the long-term outcome of CBT for MS-related fatigue.TRIAL REGISTRATION: Dutch Trial Register (NTR6966), registered 18 January 2018 https://www.trialregister.nl/trial/6782.

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KW - booster sessions

KW - cognitive behavioural therapy

KW - e-health

KW - long-term effects

KW - randomized controlled trial

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DO - https://doi.org/10.1177/13524585231213258

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JO - Multiple sclerosis (Houndmills, Basingstoke, England)

JF - Multiple sclerosis (Houndmills, Basingstoke, England)

IS - 1

ER -

Effectiveness of a blended booster programme for the long-term outcome of cognitive behavioural therapy for MS-related fatigue: A randomized controlled trial

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