Effectiveness of Omicron XBB.1.5 vaccine against infection with SARS-CoV-2 Omicron XBB and JN.1 variants, prospective cohort study, the Netherlands, October 2023 to January 2024

Anne J. Huiberts, Christina E. Hoeve, Brechje de Gier, Jeroen Cremer, Bas van der Veer, Hester E. de Melker, Janneke H. H. M. van de Wijgert, Susan van den Hof, Dirk Eggink, Mirjam J. Knol

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Abstract

We estimated vaccine effectiveness (VE) of SARSCoV- 2 Omicron XBB.1.5 vaccination against selfreported infection between 9 October 2023 and 9 January 2024 in 23,895 XBB.1.5 vaccine-eligible adults who had previously received at least one booster. VE was 41% (95% CI: 23-55) in 18-59-year-olds and 50% (95% CI: 44-56) in 60-85-year-olds. Sequencing data suggest lower protection against the BA.2.86 (including JN.1) variant from recent prior infection (OR = 2.8; 95% CI:1.2-6.5) and, not statistically significant, from XBB.1.5 vaccination (OR = 1.5; 95% CI:0.8-2.6).
Original languageEnglish
Article numbere2400109
JournalEurosurveillance
Volume29
Issue number10
DOIs
Publication statusPublished - 7 Mar 2024

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