Abstract
Background
The immune system plays an important role in tumour immune surveillance. Head and neck squamous cell carcinoma patients are often immune compromised.
Objective
To chart the baseline levels of T-cell subpopulation frequencies in patients with cancer prior to treatment.
Subjects and methods
Blood samples of patients were taken at the time of diagnosis, analysed with flowcytometry and compared with blood samples of healthy donors.
Results
Compared to healthy donors, a significant shift from naive to effector memory T cells was observed. This effect was most prominent in stage II patients. A similar shift from naive to effector memory T cells was noted in patients with oropharynx or larynx squamous cell carcinomas. Furthermore, the percentage of effector memory and effector T cells was higher in the group of patients with human papillomavirus-positive oropharyngeal squamous cell carcinomas, compared with patients with human papillomavirus-negative tumours, suggestive of virus-induced T-cell activation.
Conclusion
Here, we provide a simple and easily implementable tool to document T lymphocyte subsets in the peripheral blood of head and neck cancer patients, which might be useful for prognosis and/or therapy response prediction.
The immune system plays an important role in tumour immune surveillance. Head and neck squamous cell carcinoma patients are often immune compromised.
Objective
To chart the baseline levels of T-cell subpopulation frequencies in patients with cancer prior to treatment.
Subjects and methods
Blood samples of patients were taken at the time of diagnosis, analysed with flowcytometry and compared with blood samples of healthy donors.
Results
Compared to healthy donors, a significant shift from naive to effector memory T cells was observed. This effect was most prominent in stage II patients. A similar shift from naive to effector memory T cells was noted in patients with oropharynx or larynx squamous cell carcinomas. Furthermore, the percentage of effector memory and effector T cells was higher in the group of patients with human papillomavirus-positive oropharyngeal squamous cell carcinomas, compared with patients with human papillomavirus-negative tumours, suggestive of virus-induced T-cell activation.
Conclusion
Here, we provide a simple and easily implementable tool to document T lymphocyte subsets in the peripheral blood of head and neck cancer patients, which might be useful for prognosis and/or therapy response prediction.
| Original language | English |
|---|---|
| Pages (from-to) | 577-584 |
| Journal | Oral diseases |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2013 |
