TY - JOUR
T1 - Effects of a high-protein intake on metabolic targets for weight loss in children with obesity: a randomized trial
T2 - a randomized trial
AU - Veldhorst, M. A. B.
AU - Verbruggen, S. C. A. T.
AU - van Harskamp, D.
AU - Vermes, A.
AU - Schierbeek, H.
AU - van Goudoever, J. B.
AU - van den Akker, E. L. T.
PY - 2018/8
Y1 - 2018/8
N2 - Objective: The objective of this research is to study effects of a 4-week high-protein (HP) diet on energy intake, resting energy expenditure (REE), protein turnover and body composition in children with obesity. Methods: In this randomized placebo-controlled single-blind crossover study, children with obesity (n = 14; mean age: 10.1 years ± 1.2 standard deviation; body mass index–standard deviation score [BMI-SDS]: 2.8 ± 0.5) received an ad libitum HP (+50 g protein per day) or normal-protein (NP) diet for 4 weeks with a washout period of ≥2 weeks. Energy intake, REE, protein turnover, weight, BMI-SDS and body composition were measured. Results: No differences were found in energy intake or REE between HP and NP. There was an increased urea production and phenylalanine hydroxylation after HP compared with NP (p < 0.05). There was an increased rise in fat-free mass after HP compared with NP (∆HP: 0.8 ± 0.8 kg vs. ∆NP: 0.1 ± 0.6 kg, p < 0.05). BMI and BMI-SDS increased during the study (BMI-SDS start: 2.8 ± 0.5, end: 2.9 ± 0.5, p < 0.05) without a difference between groups. Conclusions: A 4-week HP diet with ad libitum food intake did not affect energy intake and energy expenditure in children with obesity. BMI increased, although that could be partly explained by an increase in fat-free mass.
AB - Objective: The objective of this research is to study effects of a 4-week high-protein (HP) diet on energy intake, resting energy expenditure (REE), protein turnover and body composition in children with obesity. Methods: In this randomized placebo-controlled single-blind crossover study, children with obesity (n = 14; mean age: 10.1 years ± 1.2 standard deviation; body mass index–standard deviation score [BMI-SDS]: 2.8 ± 0.5) received an ad libitum HP (+50 g protein per day) or normal-protein (NP) diet for 4 weeks with a washout period of ≥2 weeks. Energy intake, REE, protein turnover, weight, BMI-SDS and body composition were measured. Results: No differences were found in energy intake or REE between HP and NP. There was an increased urea production and phenylalanine hydroxylation after HP compared with NP (p < 0.05). There was an increased rise in fat-free mass after HP compared with NP (∆HP: 0.8 ± 0.8 kg vs. ∆NP: 0.1 ± 0.6 kg, p < 0.05). BMI and BMI-SDS increased during the study (BMI-SDS start: 2.8 ± 0.5, end: 2.9 ± 0.5, p < 0.05) without a difference between groups. Conclusions: A 4-week HP diet with ad libitum food intake did not affect energy intake and energy expenditure in children with obesity. BMI increased, although that could be partly explained by an increase in fat-free mass.
KW - Body composition
KW - dietary protein
KW - energy expenditure
KW - protein turnover
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85080842668&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30151229
UR - http://www.scopus.com/inward/record.url?scp=85080842668&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/osp4.277
DO - https://doi.org/10.1002/osp4.277
M3 - Article
C2 - 30151229
SN - 2055-2238
VL - 4
SP - 347
EP - 356
JO - Obesity Science and Practice
JF - Obesity Science and Practice
IS - 4
ER -