TY - JOUR
T1 - Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects
AU - van Nierop, F. Samuel
AU - Kulik, W.
AU - Endert, Erik
AU - Schaap, Frank G.
AU - Olde Damink, Steven W.
AU - Romijn, Johannes A.
AU - Soeters, Maarten R.
PY - 2017
Y1 - 2017
N2 - Background & aims: Bile acids (BA) are pleiotropic hormones affecting glucose and lipid metabolism. The physiochemical properties of different BA species affect their enterohepatic dynamics and their affinity for bile acid receptors. The BA pool composition is altered in patients with type 2 diabetes and obesity. In this study we used a 2-week very-low-calorie diet (VLCD) to investigate the effects of weight loss on BA pool composition and postprandial dynamics. Methods: We performed mixed meal tests in obese, insulin resistant subjects before and after the VLCD. We measured postprandial plasma levels of glucose, insulin, BA and the BA-induced enterokine fibroblast growth factor 19 (FGF19). Results: The VLCD decreased weight by 4.5 +/- 2.3 kg (p <0.0001) within 14 days. Weight loss increased peak postprandial deoxycholate (DCA) levels (median [IQR]: 0.90 [0.90] vs. 1.25 [135] mu mol/L; p = 0.045*). Other BA species, glucose, insulin and FGF19 levels and prandial excursions were not significantly affected. The VLCD decreased resting and postprandial energy expenditure by 7 and 11% respectively. Conclusions: VLCD induced weight loss increased postprandial DCA peak levels and decreased resting energy expenditure in obese insulin resistant subjects. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved
AB - Background & aims: Bile acids (BA) are pleiotropic hormones affecting glucose and lipid metabolism. The physiochemical properties of different BA species affect their enterohepatic dynamics and their affinity for bile acid receptors. The BA pool composition is altered in patients with type 2 diabetes and obesity. In this study we used a 2-week very-low-calorie diet (VLCD) to investigate the effects of weight loss on BA pool composition and postprandial dynamics. Methods: We performed mixed meal tests in obese, insulin resistant subjects before and after the VLCD. We measured postprandial plasma levels of glucose, insulin, BA and the BA-induced enterokine fibroblast growth factor 19 (FGF19). Results: The VLCD decreased weight by 4.5 +/- 2.3 kg (p <0.0001) within 14 days. Weight loss increased peak postprandial deoxycholate (DCA) levels (median [IQR]: 0.90 [0.90] vs. 1.25 [135] mu mol/L; p = 0.045*). Other BA species, glucose, insulin and FGF19 levels and prandial excursions were not significantly affected. The VLCD decreased resting and postprandial energy expenditure by 7 and 11% respectively. Conclusions: VLCD induced weight loss increased postprandial DCA peak levels and decreased resting energy expenditure in obese insulin resistant subjects. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved
U2 - https://doi.org/10.1016/j.clnu.2016.10.006
DO - https://doi.org/10.1016/j.clnu.2016.10.006
M3 - Article
C2 - 27773549
SN - 0261-5614
VL - 36
SP - 1615
EP - 1620
JO - Clinical nutrition (Edinburgh, Scotland)
JF - Clinical nutrition (Edinburgh, Scotland)
IS - 6
ER -