TY - JOUR
T1 - Effects of age, race, and ethnicity on the optic nerve and peripapillary region using spectral-domain OCT 3d volume scans
AU - Poon, Linda Yi-Chieh
AU - Antar, Hussein
AU - Tsikata, Edem
AU - Guo, Rong
AU - Papadogeorgou, Georgia
AU - Freeman, Madeline
AU - Khoueir, Ziad
AU - Lee, Ramon
AU - Shieh, Eric
AU - Simavli, Huseyin
AU - Que, Christian John
AU - de Boer, Johannes F.
AU - Chen, Teresa C.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects. Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV). Custom-designed software calculated neuroretinal rim minimum distance band (MDB) thickness and area. Results: There were 272 normal subjects, including 175 whites, 40 blacks, 40 Asians, and 17 Hispanics. Rates of age-related decline were 2.3%, 2.0%, 1.7%, 3.3%, and 4.3% per decade for RNFL, RT, RV, MDB neuroretinal rim thickness, and MDB area, respectively. The RNFL was most affected by racial and ethnic variations, with Asians having thicker global, superior, and inferior RNFL, Hispanics having thicker inferior RNFL, and blacks having thinner temporal RNFL, compared to whites. For MDB thickness and area, Asians had smaller nasal values and blacks had smaller temporal values. Peripapillary RT and RV parameters were not influenced by race and ethnicity. Conclusions: All of the parameters exhibited age-related declines. RNFL, MDB thickness, and MDB area demonstrated racial and ethnic variations, while peripapillary RT and RV did not. Translational Relevance: This study demonstrates that both normal aging and ethnicity affect several novel 3D OCT parameters used to diagnose and monitor glaucoma (i.e., RT, RV, and MDB), and this should be factored in when making clinical decisions based on these parameters.
AB - Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects. Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV). Custom-designed software calculated neuroretinal rim minimum distance band (MDB) thickness and area. Results: There were 272 normal subjects, including 175 whites, 40 blacks, 40 Asians, and 17 Hispanics. Rates of age-related decline were 2.3%, 2.0%, 1.7%, 3.3%, and 4.3% per decade for RNFL, RT, RV, MDB neuroretinal rim thickness, and MDB area, respectively. The RNFL was most affected by racial and ethnic variations, with Asians having thicker global, superior, and inferior RNFL, Hispanics having thicker inferior RNFL, and blacks having thinner temporal RNFL, compared to whites. For MDB thickness and area, Asians had smaller nasal values and blacks had smaller temporal values. Peripapillary RT and RV parameters were not influenced by race and ethnicity. Conclusions: All of the parameters exhibited age-related declines. RNFL, MDB thickness, and MDB area demonstrated racial and ethnic variations, while peripapillary RT and RV did not. Translational Relevance: This study demonstrates that both normal aging and ethnicity affect several novel 3D OCT parameters used to diagnose and monitor glaucoma (i.e., RT, RV, and MDB), and this should be factored in when making clinical decisions based on these parameters.
KW - Age
KW - Aging
KW - Optic nerve
KW - Peripapillary retina
KW - Race
KW - Spectral-domain OCT
KW - Three-dimensional OCT
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059254410&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30510856
UR - http://www.scopus.com/inward/record.url?scp=85059254410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059254410&partnerID=8YFLogxK
U2 - https://doi.org/10.1167/tvst.7.6.12
DO - https://doi.org/10.1167/tvst.7.6.12
M3 - Article
C2 - 30510856
SN - 2164-2591
VL - 7
SP - 1
EP - 13
JO - Translational Vision Science and Technology
JF - Translational Vision Science and Technology
IS - 6
M1 - 12
ER -