TY - JOUR
T1 - Effects of C-Reactive Protein and Cholesterol on Responsiveness In Vitro of the Internal Thoracic Artery to Angiotensin II in Patients Having Coronary Artery Bypass Grafting
AU - van der Harst, Pim
AU - Asselbergs, Folkert W.
AU - Buikema, Hendrik
AU - Voors, Adriaan A.
AU - van Veldhuisen, Dirk J.
AU - van Gilst, Wiek H.
PY - 2006/9/8
Y1 - 2006/9/8
N2 - The renin-angiotensin system is critically involved in the pathogenesis of atherosclerosis. Cholesterol increases vascular responsiveness to angiotensin II by upregulation of the angiotensin II type 1 receptor. However, the effects of C-reactive protein (CRP) on vascular responsiveness to angiotensin II are unknown. We evaluated, in vitro, the vascular responsiveness of the internal thoracic artery to angiotensin II in patients who underwent coronary bypass grafting. We observed that increased preoperative CRP and increased cholesterol levels were strongly related to increased vascular responsiveness to angiotensin II (p <0.001 for the 2 comparisons). However, angiotensin II-mediated contraction was increased only when levels of CRP and cholesterol were jointly increased. In conclusion, our results suggest that CRP and cholesterol act synergistically on vascular responsiveness to angiotensin II. © 2006 Elsevier Inc. All rights reserved.
AB - The renin-angiotensin system is critically involved in the pathogenesis of atherosclerosis. Cholesterol increases vascular responsiveness to angiotensin II by upregulation of the angiotensin II type 1 receptor. However, the effects of C-reactive protein (CRP) on vascular responsiveness to angiotensin II are unknown. We evaluated, in vitro, the vascular responsiveness of the internal thoracic artery to angiotensin II in patients who underwent coronary bypass grafting. We observed that increased preoperative CRP and increased cholesterol levels were strongly related to increased vascular responsiveness to angiotensin II (p <0.001 for the 2 comparisons). However, angiotensin II-mediated contraction was increased only when levels of CRP and cholesterol were jointly increased. In conclusion, our results suggest that CRP and cholesterol act synergistically on vascular responsiveness to angiotensin II. © 2006 Elsevier Inc. All rights reserved.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748089330&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/16950177
U2 - https://doi.org/10.1016/j.amjcard.2006.04.010
DO - https://doi.org/10.1016/j.amjcard.2006.04.010
M3 - Article
C2 - 16950177
SN - 0002-9149
VL - 98
SP - 751
EP - 753
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -