Effects of Chemotherapy on Neurocognitive Function in Children With Acute Lymphoblastic Leukemia: A Critical Review of the Literature

A.I. Buizer; L.M.J. de Sonneville; A.J.P. Veerman

doi:https://doi.org/10.1002/pbc.21869

Effects of Chemotherapy on Neurocognitive Function in Children With Acute Lymphoblastic Leukemia: A Critical Review of the Literature

A.I. Buizer, L.M.J. de Sonneville, A.J.P. Veerman

Research output: Contribution to journal › Article › Academic › peer-review

148 Citations (Scopus)

Abstract

Chemotherapy-only treatment has increasingly become the standard of treatment for childhood acute lymphoblastic leukemia (ALL). The objective of this review is to assess the present state of knowledge of the neurocognitive effects of central nervous system (CNS)-directed chemotherapy in children with ALL, and to formulate directions for future research. We performed a review of studies published since 1997, that included an ALL group treated with chemotherapy only and a control group. Twenty-one studies met our inclusion criteria. There is evidence of subtle long-term neurocognitive deficits survivors of childhood ALL after treatment with chemotherapy only. These involve mainly processes of attention and of executive functioning, while global intellectual function is relatively preserved. Young age at diagnosis and female sex emerged as risk factors. Pediatr Blood Cancer 2009;52: 447-454. (c) 2008 Wiley-Liss, Inc

Original language	Undefined/Unknown
Pages (from-to)	447-454
Journal	Pediatric Blood and Cancer
Volume	52
Issue number	4
DOIs	https://doi.org/10.1002/pbc.21869
Publication status	Published - 2009

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https://doi.org/10.1002/pbc.21869

Cite this

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title = "Effects of Chemotherapy on Neurocognitive Function in Children With Acute Lymphoblastic Leukemia: A Critical Review of the Literature",

abstract = "Chemotherapy-only treatment has increasingly become the standard of treatment for childhood acute lymphoblastic leukemia (ALL). The objective of this review is to assess the present state of knowledge of the neurocognitive effects of central nervous system (CNS)-directed chemotherapy in children with ALL, and to formulate directions for future research. We performed a review of studies published since 1997, that included an ALL group treated with chemotherapy only and a control group. Twenty-one studies met our inclusion criteria. There is evidence of subtle long-term neurocognitive deficits survivors of childhood ALL after treatment with chemotherapy only. These involve mainly processes of attention and of executive functioning, while global intellectual function is relatively preserved. Young age at diagnosis and female sex emerged as risk factors. Pediatr Blood Cancer 2009;52: 447-454. (c) 2008 Wiley-Liss, Inc",

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