Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS

L. van Bloemendaal; J.S. ten Kulve; S.E. la Fleur; R.G. IJzerman; M. Diamant

doi:https://doi.org/10.1530/JOE-13-0414

Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS

L. van Bloemendaal, J.S. ten Kulve, S.E. la Fleur, R.G. IJzerman, M. Diamant

Research output: Contribution to journal › Article › Academic › peer-review

197 Citations (Scopus)

Abstract

The delivery of nutrients to the gastrointestinal tract after food ingestion activates the secretion of several gut-derived mediators, including the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 receptor agonists (GLP-1RA), such as exenatide and liraglutide, are currently employed successfully in the treatment of patients with type 2 diabetes mellitus. GLP-1RA improve glycaemic control and stimulate satiety, leading to reductions in food intake and body weight. Besides gastric distension and peripheral vagal nerve activation, GLP-1RA induce satiety by influencing brain regions involved in the regulation of feeding, and several routes of action have been proposed. This review summarises the evidence for a physiological role of GLP-1 in the central regulation of feeding behaviour and the different routes of action involved. Also, we provide an overview of presently available data on pharmacological stimulation of GLP-1 pathways leading to alterations in CNS activity, reductions in food intake and weight loss

Original language	English
Pages (from-to)	T1-T16
Journal	Journal of endocrinology
Volume	221
Issue number	1
DOIs	https://doi.org/10.1530/JOE-13-0414
Publication status	Published - 2014

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https://doi.org/10.1530/JOE-13-0414

Cite this

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title = "Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS",

abstract = "The delivery of nutrients to the gastrointestinal tract after food ingestion activates the secretion of several gut-derived mediators, including the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 receptor agonists (GLP-1RA), such as exenatide and liraglutide, are currently employed successfully in the treatment of patients with type 2 diabetes mellitus. GLP-1RA improve glycaemic control and stimulate satiety, leading to reductions in food intake and body weight. Besides gastric distension and peripheral vagal nerve activation, GLP-1RA induce satiety by influencing brain regions involved in the regulation of feeding, and several routes of action have been proposed. This review summarises the evidence for a physiological role of GLP-1 in the central regulation of feeding behaviour and the different routes of action involved. Also, we provide an overview of presently available data on pharmacological stimulation of GLP-1 pathways leading to alterations in CNS activity, reductions in food intake and weight loss",

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AU - van Bloemendaal, L.

AU - ten Kulve, J.S.

AU - la Fleur, S.E.

AU - IJzerman, R.G.

AU - Diamant, M.

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AB - The delivery of nutrients to the gastrointestinal tract after food ingestion activates the secretion of several gut-derived mediators, including the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 receptor agonists (GLP-1RA), such as exenatide and liraglutide, are currently employed successfully in the treatment of patients with type 2 diabetes mellitus. GLP-1RA improve glycaemic control and stimulate satiety, leading to reductions in food intake and body weight. Besides gastric distension and peripheral vagal nerve activation, GLP-1RA induce satiety by influencing brain regions involved in the regulation of feeding, and several routes of action have been proposed. This review summarises the evidence for a physiological role of GLP-1 in the central regulation of feeding behaviour and the different routes of action involved. Also, we provide an overview of presently available data on pharmacological stimulation of GLP-1 pathways leading to alterations in CNS activity, reductions in food intake and weight loss

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