Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial

Abraham H. Hulst, Maarten J. Visscher, Thomas G.V. Cherpanath, Lieke van de Wouw, Marc B. Godfried, Bram Thiel, Bastiaan M. Gerritse, Thierry V. Scohy, R. Arthur Bouwman, Mark G.A. Willemsen, Markus W. Hollmann, J. Hans Devries, Benedikt Preckel, Jeroen Hermanides

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Abstract

Introduction: Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery. Methods: We performed a pre-planned secondary analysis of adult patients undergoing cardiac surgery included in the GLOBE trial. Patients were randomised to receive 0.6 mg subcutaneous liraglutide on the evening before surgery and 1.2 mg after induction of anaesthesia, or matching placebo. Perioperative echocardiographic assessments, haemodynamic parameters, doses of vasoactive inotropic support and postoperative measurements of troponin, Creatine Kinase-MB, creatinine and lactate were compared between groups. Results: The study population consisted of the entire intention-to-treat cohort of the GLOBE trial. In this study, 129 patients received liraglutide and 132 patients placebo. Baseline characteristics were comparable between groups. Postoperatively, 170 (65%) patients underwent echocardiography. In the liraglutide group, more patients had a normal left ventricular systolic function (68%, 59 patients) compared to placebo (53%, 44 patients), difference = 15%, 95%CI = 0–30, p = 0.049. Assessment of the right ventricle revealed no difference in function. Conclusions: Patients receiving short-term preoperative liraglutide treatment better maintained normal myocardial function after cardiac surgery. This study warrants further evaluation of the potential beneficial effects of GLP-1 receptor agonists in cardiac surgery patients.

Original languageEnglish
Article number673
JournalJournal of Clinical Medicine
Volume9
Issue number3
DOIs
Publication statusPublished - 2 Mar 2020

Keywords

  • CK-MB
  • Cardiac function
  • Echocardiography
  • Left ventricular function
  • Liraglutide
  • Placebo
  • Randomised controlled trial
  • Troponin

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