TY - JOUR
T1 - Effects of mandibular advancement devices on upper airway dimensions in obstructive sleep apnea: responders versus non-responders
T2 - responders versus non-responders
AU - Shi, Xiaoxin
AU - Lobbezoo, Frank
AU - Chen, Hui
AU - Rosenmöller, Boudewijn R.A.M.
AU - Berkhout, Erwin
AU - de Lange, Jan
AU - Aarab, Ghizlane
N1 - Funding Information: Xiaoxin Shi has received a scholarship from the China Scholarship Council. Funding Information: We gratefully acknowledge the statistical advice of Dr. Naichuan Su, department of Oral Public Health, Academic Centre for Dentistry Amsterdam (ACTA). Publisher Copyright: © 2023, The Author(s).
PY - 2023/9
Y1 - 2023/9
N2 - Study objectives: To compare the effects of mandibular advancement device (MAD) therapy on upper airway dimensions between responders and non-responders with mild to moderate obstructive sleep apnea (OSA). Methods: Thirty-one participants (21 men and 10 women) with a mean ± SD apnea-hypopnea index (AHI) of 16.6 ± 6.7 events/h, and aged 48.5 ± 13.9 years, were included in this study. Polysomnographic recordings and cone beam computed tomography (CBCT) scans in supine position were performed for every participant at baseline and at 3-month follow-up with their MAD in situ. Responders were defined as having ≥ 50% reduction in baseline AHI with a residual AHI < 10 events/h. The primary outcome variable was the minimal cross-sectional area of the upper airway (CSAmin). Results: No significant differences were found between responders (n = 15) and non-responders (n = 16) in age, gender distribution, body mass index, and neck circumference (P = 0.06–0.93), nor in AHI and CSAmin (P = 0.40 and 0.65, respectively) at baseline. The changes of the CSAmin with MAD in situ in the responder group were not significantly different compared to those in the non-responder group (P = 0.06). Conclusion: Within the limitations of this study, we conclude that the changes of the upper airway dimensions induced by MADs are not significantly different between responders and non-responders with mild to moderate OSA. Trial registration: ClinicalTrials.gov Identifier: NCT02724865. https://clinicaltrials.gov/ct2/show/NCT02724865
AB - Study objectives: To compare the effects of mandibular advancement device (MAD) therapy on upper airway dimensions between responders and non-responders with mild to moderate obstructive sleep apnea (OSA). Methods: Thirty-one participants (21 men and 10 women) with a mean ± SD apnea-hypopnea index (AHI) of 16.6 ± 6.7 events/h, and aged 48.5 ± 13.9 years, were included in this study. Polysomnographic recordings and cone beam computed tomography (CBCT) scans in supine position were performed for every participant at baseline and at 3-month follow-up with their MAD in situ. Responders were defined as having ≥ 50% reduction in baseline AHI with a residual AHI < 10 events/h. The primary outcome variable was the minimal cross-sectional area of the upper airway (CSAmin). Results: No significant differences were found between responders (n = 15) and non-responders (n = 16) in age, gender distribution, body mass index, and neck circumference (P = 0.06–0.93), nor in AHI and CSAmin (P = 0.40 and 0.65, respectively) at baseline. The changes of the CSAmin with MAD in situ in the responder group were not significantly different compared to those in the non-responder group (P = 0.06). Conclusion: Within the limitations of this study, we conclude that the changes of the upper airway dimensions induced by MADs are not significantly different between responders and non-responders with mild to moderate OSA. Trial registration: ClinicalTrials.gov Identifier: NCT02724865. https://clinicaltrials.gov/ct2/show/NCT02724865
KW - Cone beam computed tomography
KW - Mandibular advancement device
KW - Obstructive sleep apnea
KW - Treatment response
KW - Upper airway dimensions
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U2 - https://doi.org/10.1007/s00784-023-05186-w
DO - https://doi.org/10.1007/s00784-023-05186-w
M3 - Article
C2 - 37589748
SN - 1432-6981
VL - 27
SP - 5649
EP - 5660
JO - Clinical Oral Investigations
JF - Clinical Oral Investigations
IS - 9
ER -