Effects of Perinatal Exposure to PCBs on Neuropsychological Functions in the Rotterdam Cohort at 9 Years of Age

Hestein J.I. Vreugdenhil, Harry H. Emmen, Paul G.H. Mulder, Nynke Weisglas-Kuperus

Research output: Contribution to journalArticleAcademicpeer-review

83 Citations (Scopus)


PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB-dioxin cohort, higher prenatal PCB levels were associated with longer response times (RTs), more variation in RTs, and lower scores on the Tower of London (TOL; Shallice, 1982). A longer breast-feeding duration was associated with lower TOL scores and with better spatial organizational skills. There was some evidence of negative effects of lactational exposure to PCBs on scores on the TOL.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
Issue number1
Publication statusPublished - 1 Jan 2004

Cite this