TY - JOUR
T1 - Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices
AU - Münker, T.J.A.G.
AU - van de Vijfeijken, S.E.C.M.
AU - Mulder, C.S.
AU - Vespasiano, V.
AU - Becking, A.G.
AU - Kleverlaan, C.J.
AU - On behalf of the CranioSafe Group
AU - Becking, A.G.
AU - Dubois, L.
AU - Karssemakers, L.H.E.
AU - Milstein, D.M.J.
AU - van de Vijfeijken, S.E.C.M.
AU - Depauw, P.R.A.M.
AU - Hoefnagels, F.W.A.
AU - Vandertop, W.P.
AU - Kleverlaan, C.J.
AU - Münker, T.J.A.G.
AU - Maal, T.J.J.
AU - Nout, E.
AU - Riool, M.
AU - Zaat, S.A.J.
AU - CranioSafe Group
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background: Nowadays, personalized medical devices are frequently used for patients. Due to the manufacturing procedure sterilization is required. How different sterilization methods affect the mechanical behavior of these devices is largely unknown. Materials and methods: Three poly(methyl methacrylate) (PMMA) based materials (Vertex Self-Curing, Palacos R+G, and NextDent C&B MFH) were sterilized with different sterilization methods: ethylene oxide, hydrogen peroxide gas plasma, autoclavation, and γ-irradiation. Mechanical properties were determined by testing the flexural strength, flexural modulus, fracture toughness, and impact strength. Results: The flexural strength of all materials was significantly higher after γ-irradiation compared to the control and other sterilization methods, as tested in a wet environment. NextDent C&B MFH showed the highest flexural and impact strength, Palacos R+G showed the highest maximum stress intensity factor and total fracture work. Conclusion: Autoclave sterilization is not suitable for the sterilization of PMMA-based materials. Ethylene oxide, hydrogen peroxide gas plasma, and γ-irradiation appear to be suitable techniques to sterilize PMMA-based personalized medical devices.
AB - Background: Nowadays, personalized medical devices are frequently used for patients. Due to the manufacturing procedure sterilization is required. How different sterilization methods affect the mechanical behavior of these devices is largely unknown. Materials and methods: Three poly(methyl methacrylate) (PMMA) based materials (Vertex Self-Curing, Palacos R+G, and NextDent C&B MFH) were sterilized with different sterilization methods: ethylene oxide, hydrogen peroxide gas plasma, autoclavation, and γ-irradiation. Mechanical properties were determined by testing the flexural strength, flexural modulus, fracture toughness, and impact strength. Results: The flexural strength of all materials was significantly higher after γ-irradiation compared to the control and other sterilization methods, as tested in a wet environment. NextDent C&B MFH showed the highest flexural and impact strength, Palacos R+G showed the highest maximum stress intensity factor and total fracture work. Conclusion: Autoclave sterilization is not suitable for the sterilization of PMMA-based materials. Ethylene oxide, hydrogen peroxide gas plasma, and γ-irradiation appear to be suitable techniques to sterilize PMMA-based personalized medical devices.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042916019&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29524755
U2 - https://doi.org/10.1016/j.jmbbm.2018.01.033
DO - https://doi.org/10.1016/j.jmbbm.2018.01.033
M3 - Article
C2 - 29524755
SN - 1751-6161
VL - 81
SP - 168
EP - 172
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
ER -