Efficacious dosing regimens for anti-TNF therapies in inflammatory bowel disease: where do we stand?

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Scopus)

Abstract

Introduction: During the last decades, biologics have revolutionized the treatment of Crohn’s disease and ulcerative colitis. Even though the inflammatory bowel disease (IBD) armamentarium is rapidly expanding with novel biologics, anti-tumor necrosis factor (TNF) antibodies remain the first-line biologic therapy in most areas of the world. However, anti-TNF therapy is not effective in all patients (primary non-response) and patients can lose effect over time (secondary loss of response). Areas covered: This review provides an overview of the current induction and maintenance dosing regimens of the available anti-TNF antibodies and associated challenges in adult patients with IBD. We outline different strategies to overcome these difficulties, including combination therapy, therapeutic drug monitoring (TDM), and dose escalation. Finally, we discuss expected future progress in anti-TNF management. Expert opinion: Anti-TNF agents will remain a cornerstone of IBD treatment in the coming decade. Progress will be made in biomarkers for the prediction of response and individualized dosing regimens. The advent of subcutaneous infliximab challenges the need for concomitant immunosuppression.
Original languageEnglish
Pages (from-to)341-351
Number of pages11
JournalExpert Opinion on Biological Therapy
Volume23
Issue number4
Early online date2023
DOIs
Publication statusPublished - 2023

Keywords

  • Anti-TNF
  • Anti-drug antibody
  • dosing regimens
  • immunogenicity
  • inflammatory bowel disease
  • personalized medicine
  • therapeutic drug monitoring
  • trough level

Cite this