TY - JOUR
T1 - Efficacy and moderators of short-term psychodynamic psychotherapy for depression
T2 - A systematic review and meta-analysis of individual participant data
AU - Wienicke, Frederik J.
AU - Beutel, Manfred E.
AU - Zwerenz, R. diger
AU - Brähler, Elmar
AU - Fonagy, Peter
AU - Luyten, Patrick
AU - Constantinou, Matthew
AU - Barber, Jacques P.
AU - McCarthy, Kevin S.
AU - Solomonov, Nili
AU - Cooper, Peter J.
AU - de Pascalis, Leonardo
AU - Johansson, Robert
AU - Andersson, Gerhard
AU - Lemma, Alessandra
AU - Town, Joel M.
AU - Abbass, Allan A.
AU - Ajilchi, Bita
AU - Connolly Gibbons, Mary Beth
AU - López-Rodríguez, Jaime
AU - Villamil-Salcedo, Valerio
AU - Maina, Giuseppe
AU - Rosso, Gianluca
AU - Twisk, Jos W. R.
AU - Burk, William J.
AU - Spijker, Jan
AU - Cuijpers, Pim
AU - Driessen, Ellen
N1 - Funding Information: Recruitment of individual participant data for this work was supported by a Fund for Psychoanalytic Research of the American Psychoanalytic Association [no grant number]. This study was further financed by the Netherlands Organization of Scientific Research (NWO): 016.Veni.195.2156806. The funding organizations had no role in the study design, collection, analysis, or interpretation of the data, writing the manuscript, or the decision to submit the manuscript for publication. Publisher Copyright: © 2023 The Authors
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Background: Short-term psychodynamic psychotherapy (STPP) is frequently used to treat depression, but it is unclear which patients might benefit specifically. Individual participant data (IPD) meta-analyses can provide more precise effect estimates than conventional meta-analyses and identify patient-level moderators. This IPD meta-analysis examined the efficacy and moderators of STPP for depression compared to control conditions. Methods: PubMed, PsycInfo, Embase, and Cochrane Library were searched September 1st, 2022, to identify randomized trials comparing STPP to control conditions for adults with depression. IPD were requested and analyzed using mixed-effects models. Results: IPD were obtained from 11 of the 13 (84.6%) studies identified (n = 771/837, 92.1%; mean age = 40.8, SD = 13.3; 79.3% female). STPP resulted in significantly lower depressive symptom levels than control conditions at post-treatment (d = −0.62, 95%CI [−0.76, −0.47], p < .001). At post-treatment, STPP was more efficacious for participants with longer rather than shorter current depressive episode durations. Conclusions: These results support the evidence base of STPP for depression and indicate episode duration as an effect modifier. This moderator finding, however, is observational and requires prospective validation in future large-scale trials.
AB - Background: Short-term psychodynamic psychotherapy (STPP) is frequently used to treat depression, but it is unclear which patients might benefit specifically. Individual participant data (IPD) meta-analyses can provide more precise effect estimates than conventional meta-analyses and identify patient-level moderators. This IPD meta-analysis examined the efficacy and moderators of STPP for depression compared to control conditions. Methods: PubMed, PsycInfo, Embase, and Cochrane Library were searched September 1st, 2022, to identify randomized trials comparing STPP to control conditions for adults with depression. IPD were requested and analyzed using mixed-effects models. Results: IPD were obtained from 11 of the 13 (84.6%) studies identified (n = 771/837, 92.1%; mean age = 40.8, SD = 13.3; 79.3% female). STPP resulted in significantly lower depressive symptom levels than control conditions at post-treatment (d = −0.62, 95%CI [−0.76, −0.47], p < .001). At post-treatment, STPP was more efficacious for participants with longer rather than shorter current depressive episode durations. Conclusions: These results support the evidence base of STPP for depression and indicate episode duration as an effect modifier. This moderator finding, however, is observational and requires prospective validation in future large-scale trials.
KW - Depression
KW - Efficacy
KW - Individual participant data Meta-analysis
KW - Moderators
KW - Outcome
KW - Short-term psychodynamic psychotherapy
UR - http://www.scopus.com/inward/record.url?scp=85150446223&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150446223&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36958077
U2 - https://doi.org/10.1016/j.cpr.2023.102269
DO - https://doi.org/10.1016/j.cpr.2023.102269
M3 - Review article
C2 - 36958077
SN - 0272-7358
VL - 101
JO - Clinical psychology review
JF - Clinical psychology review
M1 - 102269
ER -