TY - JOUR
T1 - Electronic noses calibration procedure in the context of a multicentre medical study
AU - Santonico, M.
AU - Pennazza, G.
AU - Capuano, R.
AU - Falconi, C.
AU - Vink, T. J.
AU - Knobel, H. H.
AU - van der Schee, M. P.
AU - Sterk, P. J.
AU - Montuschi, P.
AU - D'Amico, A.
PY - 2012
Y1 - 2012
N2 - An overview of the scientific literature in the medical field tells us that a large part of electronic nose applications is devoted to breath analysis. A network based study can help testing the validity of this strategy when using many different devices based on identical or different technologies, in view of a use in real clinical practice. The first step is the instrument calibration using a set of key-compounds. In this work a gas sensor array based on quartz microbalance transducers functionalized with metalloporphyrins (ROW e-nose), and a Cyranose is used simultaneously in a calibration experiment with three ad hoc selected compounds: ethanol, hexane and ethyl acetate, at concentration levels around 1 ppm. These tests have demonstrated that limits of detection down to tens of ppb are possible. Moreover, a mapping between the two instruments has been performed through the calculation of a model based on Cyranose data, and applied to the ROW e-nose data, for the prediction of compound concentrations. This test has shown a good ability in concentrations prediction, with an error lower than 10 ppb. In conclusion, this study provides the first step toward quality assurance of e-nose data in the medical setting. (C) 2012 Elsevier B.V. All rights reserved
AB - An overview of the scientific literature in the medical field tells us that a large part of electronic nose applications is devoted to breath analysis. A network based study can help testing the validity of this strategy when using many different devices based on identical or different technologies, in view of a use in real clinical practice. The first step is the instrument calibration using a set of key-compounds. In this work a gas sensor array based on quartz microbalance transducers functionalized with metalloporphyrins (ROW e-nose), and a Cyranose is used simultaneously in a calibration experiment with three ad hoc selected compounds: ethanol, hexane and ethyl acetate, at concentration levels around 1 ppm. These tests have demonstrated that limits of detection down to tens of ppb are possible. Moreover, a mapping between the two instruments has been performed through the calculation of a model based on Cyranose data, and applied to the ROW e-nose data, for the prediction of compound concentrations. This test has shown a good ability in concentrations prediction, with an error lower than 10 ppb. In conclusion, this study provides the first step toward quality assurance of e-nose data in the medical setting. (C) 2012 Elsevier B.V. All rights reserved
U2 - https://doi.org/10.1016/j.snb.2012.07.042
DO - https://doi.org/10.1016/j.snb.2012.07.042
M3 - Article
SN - 0925-4005
VL - 173
SP - 555
EP - 561
JO - Sensors and Actuators B-Chemical
JF - Sensors and Actuators B-Chemical
ER -