TY - JOUR
T1 - Emerging understanding of the mechanism of action of Bronchial Thermoplasty in asthma
AU - d'Hooghe, J. N. S.
AU - ten Hacken, N. H. T.
AU - Weersink, E. J. M.
AU - Sterk, P. J.
AU - Annema, J. T.
AU - Bonta, P. I.
PY - 2018
Y1 - 2018
N2 - Bronchial Thermoplasty (BT) is an endoscopic treatment for moderate-to-severe asthma patients who are uncontrolled despite optimal medical therapy. Effectiveness of BT has been demonstrated in several randomized clinical trials. However, the asthma phenotype that benefits most of this treatment is unclear, partly because the mechanism of action is incompletely understood. BT was designed to reduce the amount of airway smooth muscle (ASM), but additional direct and indirect effects on airway pathophysiology are expected. This review will provide an overview of the different components of airway pathophysiology including remodeling, with the ASM as the key player. Current concepts in the understanding of BT clinical effectiveness with a focus on its impact on airway remodeling will be reviewed.
AB - Bronchial Thermoplasty (BT) is an endoscopic treatment for moderate-to-severe asthma patients who are uncontrolled despite optimal medical therapy. Effectiveness of BT has been demonstrated in several randomized clinical trials. However, the asthma phenotype that benefits most of this treatment is unclear, partly because the mechanism of action is incompletely understood. BT was designed to reduce the amount of airway smooth muscle (ASM), but additional direct and indirect effects on airway pathophysiology are expected. This review will provide an overview of the different components of airway pathophysiology including remodeling, with the ASM as the key player. Current concepts in the understanding of BT clinical effectiveness with a focus on its impact on airway remodeling will be reviewed.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026784140&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/28757156
U2 - https://doi.org/10.1016/j.pharmthera.2017.07.015
DO - https://doi.org/10.1016/j.pharmthera.2017.07.015
M3 - Review article
C2 - 28757156
SN - 0163-7258
VL - 181
SP - 101
EP - 107
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
ER -