TY - JOUR
T1 - Employing the immunological synapse in AML
T2 - Development of leukemic dendritic cells for active specific immunization
AU - Houtenbos, Ilse
AU - Westers, Theresia M.
AU - Ossenkoppele, Gert J.
AU - van de Loosdrecht, Arjan A.
PY - 2005/8/19
Y1 - 2005/8/19
N2 - Cytotoxic T cells directed against leukemic blasts have been observed in patients with acute myeloid leukemia (AML). However, generation of efficient T-cell responses is hampered due to several factors that enable AML blasts to protect themselves from the patients immune system. Improved immune responses can be established by the differentiation of AML blasts into AML-derived dendritic cells (DC) thereby conserving their intrinsic leukemia specific antigens and obtaining full capacity to present these antigens to naïve T cells. This review discusses increased immunogenicity of AML blasts by differentiation into AML-DC and describes ways to augment the AML-DC vaccination approach.
AB - Cytotoxic T cells directed against leukemic blasts have been observed in patients with acute myeloid leukemia (AML). However, generation of efficient T-cell responses is hampered due to several factors that enable AML blasts to protect themselves from the patients immune system. Improved immune responses can be established by the differentiation of AML blasts into AML-derived dendritic cells (DC) thereby conserving their intrinsic leukemia specific antigens and obtaining full capacity to present these antigens to naïve T cells. This review discusses increased immunogenicity of AML blasts by differentiation into AML-DC and describes ways to augment the AML-DC vaccination approach.
KW - Acute myeloid leukaemia
KW - Dendritic cells
KW - Immunological synapse
KW - Immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=22644439034&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.imbio.2005.05.019
DO - https://doi.org/10.1016/j.imbio.2005.05.019
M3 - Review article
C2 - 16164032
SN - 0171-2985
VL - 210
SP - 249
EP - 257
JO - Immunobiology
JF - Immunobiology
IS - 2-4
ER -