Abstract
In recent years, we have witnessed the many beneficial effects of glucagon-like peptide (GLP)-1 receptor agonists, including the reduction in cardiovascular risk in patients with type 2 diabetes, and the reduction of body weight in those with obesity. Increasing evidence suggests that these agents differ considerably from endogenous GLP-1 when it comes to their routes of action, although their clinical effects appear to be the same. Given the limitations of the GLP-1 receptor agonists, could it be useful to develop agents which stimulate GLP-1 release? Here we will discuss the differences and similarities between GLP-1 receptor agonists and endogenous GLP-1, and will detail how endogenous GLP-1—when stimulated appropriately—could have clinically relevant effects.
Original language | English |
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Article number | e3699 |
Journal | Diabetes/metabolism research and reviews |
Volume | 39 |
Issue number | 8 |
Early online date | 2023 |
DOIs | |
Publication status | Published - Nov 2023 |
Keywords
- diabetes
- glucagon-like peptide-1
- gut hormone
- obesity