TY - JOUR
T1 - Endoscopic full thickness resection for early colon cancer in Lynch syndrome
AU - Langers, Alexandra M.J.
AU - Boonstra, Jurjen J.
AU - Hardwick, James C.H.
AU - van der Kraan, Jolein
AU - Farina Sarasqueta, Arantza
AU - Vasen, Hans F.A.
N1 - Publisher Copyright: © 2019, The Author(s).
PY - 2019/7/15
Y1 - 2019/7/15
N2 - Subtotal colectomy is usually the therapy of choice in Lynch syndrome patients diagnosed with colon cancer. In patients who develop cancer after the age of 50–60 years, segmental colectomy is considered a good alternative. Although the endoscopic treatment of early colorectal cancer in non-Lynch patients has increased in the last decades, almost all patients with a Lynch syndrome-associated colorectal malignancy undergo surgery, even if the tumour is diagnosed in a (very) early stage. One of the endoscopic treatment options for early colorectal cancer is an endoscopic full thickness resection (eFTR). This treatment modality allows optimal pathological examination of the resection specimen, as a transmural resection is performed with optimal T-staging of the tumour. We report a case of a 62 year old man, diagnosed with MSH2-Lynch syndrome, who underwent successful eFTR treatment of an early (pT1) colon cancer located in the ascending colon, with no signs of recurrence 12 months after treatment. We discuss the pros and cons of endoscopic resection of early colorectal carcinoma in Lynch syndrome patients.
AB - Subtotal colectomy is usually the therapy of choice in Lynch syndrome patients diagnosed with colon cancer. In patients who develop cancer after the age of 50–60 years, segmental colectomy is considered a good alternative. Although the endoscopic treatment of early colorectal cancer in non-Lynch patients has increased in the last decades, almost all patients with a Lynch syndrome-associated colorectal malignancy undergo surgery, even if the tumour is diagnosed in a (very) early stage. One of the endoscopic treatment options for early colorectal cancer is an endoscopic full thickness resection (eFTR). This treatment modality allows optimal pathological examination of the resection specimen, as a transmural resection is performed with optimal T-staging of the tumour. We report a case of a 62 year old man, diagnosed with MSH2-Lynch syndrome, who underwent successful eFTR treatment of an early (pT1) colon cancer located in the ascending colon, with no signs of recurrence 12 months after treatment. We discuss the pros and cons of endoscopic resection of early colorectal carcinoma in Lynch syndrome patients.
KW - Colorectal cancer
KW - Endoscopic resection
KW - Full-thickness resection
KW - Lynch syndrome
KW - eFTR
UR - http://www.scopus.com/inward/record.url?scp=85066122006&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s10689-019-00132-w
DO - https://doi.org/10.1007/s10689-019-00132-w
M3 - Article
C2 - 31111311
SN - 1389-9600
VL - 18
SP - 349
EP - 352
JO - Familial Cancer
JF - Familial Cancer
IS - 3
ER -