Abstract
The migration of leukocytes across the endothelial lining of the vascular wall requires a complicated series of adhesion and signaling events. Endothelial Ig-like cell adhesion molecules (IgCAMs) such as intercellular adhesion molecule-1 play an important role, not only as ligands for leukocyte integrins, but also as signaling initiators. Clustering these IgCAMs triggers a wide range of events in the endothelial cells' interior, of which activation of Rho-like GTPases, induction of cytoskeletal changes, and the transient modulation of cell-cell contact are key events. This review discusses recent insights into this IgCAM-driven endothelial signaling and its consequences for leukocyte transendothelial migration.
Original language | English |
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Pages (from-to) | 1870-1876 |
Number of pages | 7 |
Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
Volume | 27 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2007 |
Keywords
- ICAM-1
- Rho GTPases
- Signaling
- Transendothelial migration
- VCAM-1